Heat shock proteins are known to be associated with a wide variety of human cancers including lung cancer. Overexpression of these molecular chaperones is linked with tumor survival, metastasis and anticancer drug resistance. In recent years, heat shock proteins are gaining much importance in the field of cancer research owing to their potential to be key determinants of cell survival and apoptosis. Lung cancer is one of the most common cancers diagnosed worldwide and the association of heat shock proteins in lung cancer diagnosis, prognosis and as drug targets remains unresolved. The aim of this review is to draw the importance of heat shock protein members; Hsp27, Hsp70, Hsp90, Hsp60 and their diagnostic and prognostic implications in lung cancer. Based on the available literature heat shock proteins can serve as biomarkers and anticancer drug targets in the management of lung cancer patients.

已知热休克蛋白与包括肺癌在内的多种人类癌症有关。这些分子伴侣的过度表达与肿瘤存活、转移和抗癌药物耐药性有关。近年来，热休克蛋白由于其可能成为细胞存活和凋亡的关键决定因素而在癌症研究领域变得越来越重要。肺癌是世界范围内最常见的癌症之一，热休克蛋白在肺癌诊断、预后和作为药物靶点中的关联仍未解决。本综述的目的是认识热休克蛋白成员的重要性；Hsp27、Hsp70、Hsp90、Hsp60 及其对肺癌的诊断和预后影响。根据现有文献，热休克蛋白可以作为肺癌患者治疗中的生物标志物和抗癌药物靶点。