Metastasis in the pineal region is a rare condition. To best of our knowledge, there is no case report of isolated pineal metastasis secondary to acute lymphocytic leukemia (ALL). The aim of this study is to show the pineal gland involvement of ALL in a case for the first time in the literature. A 25-year-old male patient diagnosed with ALL 2 years ago presented with headache and visual impairment. Brain magnetic resonance imaging (MRI) revealed a well-defined solid lesion which was revealed intensive enhancement after contrast. On diffusion-weighted images, the lesion showed significant diffusion restriction. Three months after therapy, control MRI demonstrated a completely resorbed pineal lesion. The pineal region may be a possible site of metastasis and involvement due to the absence of a blood-brain barrier, and should not be overlooked in patients with not only solid cancers but also ALL.

松果体区域的转移是一种罕见的情况。据我们所知，尚无病例报告表明急性淋巴细胞白血病（ALL）继发松果体分离。这项研究的目的是在文献中首次显示一例中ALL的松果体累及。一名2岁前诊断为ALL的25岁男性患者出现头痛和视力障碍。脑磁共振成像（MRI）显示明确的实体病变，对比后显示强化增强。在弥散加权图像上，病变显示出明显的弥散限制。治疗三个月后，对照MRI显示完全吸收了松果体病变。由于没有血脑屏障，松果体区域可能是转移和受累的可能部位，