In addition to its fundamental function as a universal cellular energy carrier, ATP has emerged as an extracellular signaling molecule with crucial roles in diverse aspects of plant growth and stress-adaptive responses (Tanaka et al. 2010). Genetic evidence identifying the first plant extracellular ATP (eATP) receptor in the plasma membrane (Choi et al. 2014) cemented eATP as an authentic signal for cell–cell communications. While the mechanisms of eATP perception and signaling are much clearer in animal cells, our understanding of equivalent mechanisms in plants is limited. Receptor activation triggers a rapid spike in cytosolic Ca²⁺ and biosynthesis of downstream messengers, such as reactive oxygen species, nitric oxide and phosphatidic acid (Tanaka et al. 2010). Converting these early biochemical responses into specific physiological outputs requires a network of signal transduction and gene-regulatory proteins with key functions in altering gene expression. Identifying such proteins should provide useful insights into how eATP works in plants.

中文翻译：

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通过发现ATP调控的转录因子揭示了对植物细胞外ATP信号的洞察力。

除了其作为通用细胞能量载体的基本功能外，ATP还作为一种细胞外信号分子而出现，在植物生长和胁迫适应性反应的各个方面都起着至关重要的作用（Tanaka等，2010）。遗传证据表明质膜中第一个植物细胞外ATP（eATP）受体（Choi等人，2014年）巩固了eATP作为细胞间通讯的真实信号。尽管在动物细胞中eATP感知和信号传导的机制更为清晰，但我们对植物等效机制的理解仍然有限。受体激活触发胞质Ca ²⁺的快速增加下游信使的生物合成，例如活性氧，一氧化氮和磷脂酸（Tanaka等，2010）。将这些早期生化反应转化为特定的生理输出，需要信号转导和基因调节蛋白网络，这些蛋白在改变基因表达中起关键作用。鉴定此类蛋白质应提供有关eATP在植物中如何工作的有用见解。