Paraneoplastic cerebellar degeneration is a neurological syndrome resulting from immune-mediated dysfunction of Purkinje cells and commonly is associated with a tumor. In most cases, well-characterized onconeural antibodies are detected, such as anti-Yo and anti-Ri antibodies. Carbonic anhydrase-related protein VIII (CARP VIII) antibodies associated with paraneoplastic cerebellar degeneration have been previously described in only two cases. Herein, we present a 75-year-old female who developed progressive cerebellar ataxia. Anti-CARP VIII autoantibodies were found at high titres and screening for underlying malignancies revealed a breast cancer. Intravenous immunoglobulin was administered with poor results. Our report further confirms the role of CARP VIII antibodies in cerebellar degeneration.

中文翻译：

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与碳酸酐酶相关蛋白 VIII 自身抗体相关的乳腺癌患者的副肿瘤性小脑变性

副肿瘤性小脑变性是一种由免疫介导的浦肯野细胞功能障碍引起的神经系统综合征，通常与肿瘤有关。在大多数情况下，可检测到特征明确的肿瘤神经抗体，例如抗 Yo 和抗 Ri 抗体。先前仅在两例病例中描述了与副肿瘤性小脑变性相关的碳酸酐酶相关蛋白 VIII (CARP VIII) 抗体。在这里，我们介绍了一名 75 岁的女性，她出现了进行性小脑性共济失调。发现高滴度的抗 CARP VIII 自身抗体，筛查潜在的恶性肿瘤揭示了乳腺癌。静脉注射免疫球蛋白效果不佳。我们的报告进一步证实了 CARP VIII 抗体在小脑变性中的作用。