Esophageal squamous cell carcinoma (ESCC) belongs to one of the most common malignant tumors worldwide and possesses high mortality. Long non‐coding RNAs (lncRNAs) have been demonstrated to be essential biological participants in the progression of ESCC. On the basis of bio‐informatics prediction, forkhead box P4 antisense RNA 1 (FOXP4‐AS1) and forkhead box P4 (FOXP4) were upregulated in esophageal carcinoma samples and were positively correlated with each other. The present study aimed to explore the function of FOXP4‐AS1 and FOXP4 in ESCC cells. Function assays disclosed that knockdown of FOXP4‐AS1 or FOXP4 efficiently suppressed cell proliferation and induced cell apoptosis. Moreover, FOXP4‐AS1 positively regulated FOXP4 by interacting with insulin‐like growth factor 2 mRNA‐binding protein 2 (IGF2BP2) to stabilize FOXP4 messenger RNA. In addition, FOXP4‐AS1 could upregulate the expression of FOXP4 by sponging miR‐3184‐5p. Finally, we found that Yin Yang 1 (YY1) is a transcription factor that can transcriptionally activate both FOXP4‐AS1 and FOXP4 in ESCC cells. In a word, YY1‐induced upregulation of FOXP4‐AS1 and FOXP4 promote the proliferation of ESCC cells

中文翻译：

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YY1诱导的FOXP4-AS1和FOXP4的上调促进食管鳞状细胞癌细胞的增殖。

食管鳞状细胞癌（ESCC）属于世界范围内最常见的恶性肿瘤之一，并具有很高的死亡率。长期的非编码RNA（lncRNA）已被证明是ESCC进展中必不可少的生物学参与者。在生物信息学预测的基础上，食管癌样本中的叉头盒P4反义RNA 1（FOXP4-AS1）和叉头盒P4（FOXP4）上调，并且彼此呈正相关。本研究旨在探索FOXP4-AS1和FOXP4在ESCC细胞中的功能。功能测定表明，敲低FOXP4-AS1或FOXP4可以有效抑制细胞增殖并诱导细胞凋亡。此外，FOXP4-AS1通过与胰岛素样生长因子2 mRNA结合蛋白2（IGF2BP2）相互作用来稳定FOXP4信使RNA，从而正向调节FOXP4。此外，FOXP4-AS1可以通过海绵miR-3184-5p上调FOXP4的表达。最后，我们发现阴阳1（YY1）是一种转录因子，可以在ESCC细胞中转录激活FOXP4-AS1和FOXP4。总之，YY1诱导的FOXP4-AS1和FOXP4的上调促进ESCC细胞的增殖