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Atrial fibrillation as an important clinical condition of cognitive decline; diagnosis, comorbidities and severity of symptoms in patients with dementia
Neurological Research ( IF 1.9 ) Pub Date : 2020-03-11 , DOI: 10.1080/01616412.2020.1738648
Natalia Niedziela 1 , Maria Magdalena Nowak 1 , Martyna Lis 1 , Maria Blaszkowska 1 , Rozalia Kośmider 1 , Monika Adamczyk-Sowa 1
Affiliation  

Objective: To determine the time of dementia diagnosis, symptom intensity and to assess the comorbidities.

Methods: 110 patients with dementia or mild cognitive impairment were enrolled in this retrospective study. The study group was divided into subgroups: patients with a maximum of three (S ≤ 3 n = 62) and four or more symptoms (S ≥ 4 n = 48). Baseline characteristics, disease duration and the number of comorbidities were analyzed.

Results: The median time from the first symptoms to diagnosis [months] (FS-D) was 12.0, while from diagnosis to enrollment (D-E) was 42.66. The median time from D-E was significantly longer in S ≥ 4 and significant correlation was observed between the median time from D-E and number of symptoms [n] (R = 0.3240, p < 0.05). Significantly more patients were newly diagnosed with AF [%] [14.58 vs. 3.23, p = 0.032], Parkinson’s disease [29.17 vs. 8.06, p = 0.004] and depression [31.25 vs. 6.45, p = 0.001] in S ≥ 4 compared to S ≤ 3, respectively. Conclusions: A considerable delay in the diagnosis of dementia was confirmed. Clinical features were associated with the disease duration and the severity of symptoms. Appropriate diagnosis of AF in patients with dementia is of great importance.



中文翻译:

心房颤动是认知功能下降的重要临床条件;痴呆患者的诊断,合并症和症状严重性

目的:确定痴呆的诊断时间,症状强度并评估合并症。

方法:本回顾性研究纳入110例痴呆或轻度认知障碍患者。研究组分为亚组:最多三个(S≤3  n = 62)和四个或更多症状(S≥4 n = 48)的患者 。分析基线特征,疾病持续时间和合并症的数量。

结果:从最初症状到诊断[个月](FS-D)的中位时间为12.0,而从诊断到入院(DE)的中位时间为42.66。在S≥4中,DE的中位时间明显更长,并且DE的中位时间与症状数[n]之间存在显着相关性(R = 0.3240,p <0.05)。显著更多的患者被新诊断为AF [%] [14.58 VS。3.23,p = 0.032],帕金森氏病[29.17 VS。8.06,p = 0.004]和抑郁[31.25 VS。6.45,S≥4时p = 0.001],而S≤3。结论:证实痴呆的诊断有相当大的延迟。临床特征与疾病持续时间和症状的严重程度有关。对痴呆患者的房颤进行适当的诊断非常重要。

更新日期:2020-04-20
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