The causes of cognitive impairment among older HIV+ individuals may overlap with causes among elderly HIV seronegative (HIV-) individuals. The objective of this study was to determine if beta-amyloid (Aβ) deposition measured by [¹⁸F] AV-45 (florbetapir) positron emission tomography (PET) is increased in older HIV+ individuals compared to HIV- individuals. Forty-eight HIV+ and 25 HIV- individuals underwent [¹⁸F] AV-45 PET imaging. [¹⁸F] AV-45 binding to Aβ was measured by standardized uptake value ratios (SUVR) relative to the cerebellum in 16 cortical and subcortical regions of interest. Global and regional cortical SUVRs were compared by (1) serostatus, (2) HAND stage, and (3) age decade, comparing individuals in their 50s and > 60s. There were no differences in median global cortical SUVR stratified by HIV serostatus or HAND stage. The proportion of HIV+ participants in their 50s with elevated global amyloid uptake (SUVR > 1.40) was significantly higher than the proportion in HIV- participants (67% versus 25%, p = 0.04), and selected regional SUVR values were also higher (p < 0.05) in HIV+ compared to HIV- participants in their 50s. However, these group differences were not seen in participants in their 60s. In conclusion, PET imaging found no differences in overall global Aβ deposition stratified by HIV serostatus or HAND stage. Although there was some evidence of increased Aβ deposition in HIV+ individuals in their 50s compared to HIV- individuals which might indicate premature aging, the most parsimonious explanation for this is the relatively small sample size in this cross-sectional cohort study.

老年HIV +个体中认知障碍的原因可能与老年HIV血清阴性（HIV-）个体的原因重叠。这项研究的目的是确定通过[ ¹⁸ F] AV-45（florbetapir）正电子发射断层显像（PET）测量的β-淀粉样蛋白（Aβ）与HIV-个体相比是否增加。对48位HIV +和25位HIV-个体进行了[ ¹⁸ F] AV-45 PET成像。[ ¹⁸ F] AV-45与Aβ的结合是通过在16个感兴趣的皮层和皮层下区域相对于小脑的标准化摄取值比（SUVR）进行测量的。通过（1）血清状态，（2）HAND阶段和（3）年龄十年比较了全球和区域皮质SUVR，比较了50多岁的个体和> 60多岁 HIV血清状态或HAND阶段分层的整体皮质SUVR中位数无差异。50年代全球淀粉样蛋白摄取量增加（SUVR> 1.40）的HIV +参与者比例显着高于HIV参与者的比例（67％对25％，p  = 0.04），并且选定的区域SUVR值也更高（p 与50年代的HIV参与者相比，HIV +中的<0.05）。但是，在60多岁的参与者中没有看到这些群体差异。总之，PET成像未发现按HIV血清状态或HAND阶段分层的总体Aβ总体沉积情况。尽管有一些证据表明，与艾滋病病毒感染者相比，艾滋病病毒感染者在50多岁时Aβ沉积增加，这可能表明过早衰老，但是对此的最简约的解释是，该横断队列研究的样本量相对较小。