Inflammation in people living with HIV (PLWH) correlates with severity of HIV-associated neurocognitive disorders. The objective of this study is to identify blood-based markers of neurocognitive function in a demographic balanced cohort of PLWH. Seven neurocognitive domains were evaluated in 121 seropositive Black/African American, Non-Hispanic White, and White Hispanic men and women using computerized assessments. Associations among standardized neurocognitive function and HIV-related parameters, relevant sociodemographic variables, and inflammation-associated cytokines measured in plasma and cellular supernatants were examined using multivariate and univariate regression models. Outlier and covariate analyses were used to identify and normalize for education level, CD4 T cell count, viral load, CNS and drug abuse comorbidities, which could influence biomarker and neurocognitive function associations. Plasma levels of chemokine (C-C motif) ligand (CCL) 8 significantly associated with memory, complex attention, cognitive flexibility, psychomotor speed, executive function, and processing speed. Plasma tissue inhibitor of metalloproteinases 1 associated with the aforementioned domains except memory and processing speed. In addition, plasma interleukin-23 significantly associated with processing speed and executive function. Analysis of peripheral blood cell culture supernatants revealed no significant markers for neurocognitive function. In this cohort, CD4 T cell count and education level also significantly associated with neurocognitive function. All identified inflammatory biomarkers demonstrated a negative correlation to neurocognitive function. These cytokines have known connections to HIV pathophysiology and are potential biomarkers for neurocognitive function in PLWH with promising clinical applications.

感染艾滋病毒的人的炎症与感染艾滋病毒的神经认知障碍的严重程度有关。这项研究的目的是在人群平衡的PLWH人群中确定基于血液的神经认知功能标记。使用计算机评估方法，在121名血清阳性的美国黑人/黑人，非西班牙裔白人和西班牙裔白人中评估了七个神经认知域。使用多变量和单变量回归模型检查了血浆和细胞上清液中标准化的神经认知功能和HIV相关参数，相关的社会人口统计学变量以及与炎症相关的细胞因子之间的关联。使用异常值和协变量分析来确定教育水平，CD4 T细胞计数，病毒载量，中枢神经系统和药物滥用合并症并进行标准化，这可能会影响生物标志物和神经认知功能的关联。血浆趋化因子（CC基序）配体（CCL）8的水平与记忆力，复杂注意力，认知柔韧性，精神运动速度，执行功能和处理速度显着相关。血浆金属蛋白酶1的组织抑制剂与上述域相关，但记忆和处理速度除外。另外，血浆白介素-23与处理速度和执行功能显着相关。外周血细胞培养上清液的分析显示，神经认知功能没有明显的标志物。在这个队列中，CD4 T细胞计数和教育水平也与神经认知功能显着相关。所有确定的炎症生物标志物均与神经认知功能呈负相关。