Salpingectomy with interval oophorectomy has gained traction as an ovarian cancer prevention strategy, but is not currently recommended for high risk women. Nevertheless, some choose this approach. We aimed to understand risk perception and plans for oophorectomy in BRCA1 and BRCA2 (BRCA) mutation carriers choosing salpingectomy for ovarian cancer prevention. This was a longitudinal survey study of BRCA mutation carriers who underwent bilateral salpingectomy to reduce ovarian cancer risk. An initial written questionnaire and telephone interview was followed by annual phone interviews. 22 women with BRCA mutations were enrolled. Median follow-up was three years. The median age at salpingectomy was 39.5 years (range 27–49). Perceived lifetime ovarian cancer risk decreased by half after salpingectomy (median risk reduction 25%, range 0–40%). At final follow-up, five (22.7%) had undergone oophorectomy and five women (22.7%) were not planning to undergo completion oophorectomy. BRCA mutation carriers who had salpingectomy after the recommended age of prophylactic surgery (vs. before the recommended age) were less likely to plan for future oophorectomy (28.6% vs. 66.7%, p = 0.037). All women were satisfied with their decision to undergo salpingectomy with eighteen (81.8%) expressing decreased cancer-related worry. There were no diagnoses of ovarian cancer during our study period. In conclusion, most BRCA mutation carriers undergoing risk-reducing salpingectomy are satisfied with their decision and have lower risk perception after salpingectomy, though some older mutation carriers did not plan on future oophorectomy. Salpingectomy with delayed oophorectomy in BRCA mutation carriers remains investigational and should preferably be performed within a clinical trial to prevent introduction of an innovation before safety has been proven.

中文翻译：

---

选择输卵管切除术预防卵巢癌的BRCA1和BRCA2突变携带者的风险和回报感知。

作为卵巢癌预防策略，输卵管切除术与间隔性卵巢切除术已获得广泛关注，但目前不建议高危女性使用。但是，有些人选择这种方法。我们旨在了解风险感知和BRCA1和BRCA2（BRCA）突变携带者选择输卵管切除术预防卵巢癌的卵巢切除术的计划。这是一项BRCA突变携带者的纵向调查研究，这些携带者接受了双侧输卵管切除术以降低卵巢癌的风险。最初的书面调查表和电话采访，然后是年度电话采访。22名BRCA女性招募了突变。中位随访时间为三年。输卵管切除术的中位年龄为39.5岁（27-49岁）。输卵管切除术后终生卵巢癌的风险降低了一半（中位风险降低25％，范围0-40％）。在最后的随访中，五名女性（22.7％）接受了卵巢切除术，五名女性（22.7％）不打算进行完全性卵巢切除术。在推荐的预防性手术年龄之后（相对于推荐的年龄之前）行输卵管切除术的BRCA突变携带者不太可能计划将来的卵巢切除术（28.6％vs. 66.7％，p = 0.037）。所有妇女都对接受输卵管切除术的决定感到满意，其中十八名（81.8％）表示减少了与癌症相关的担忧。在我们的研究期间，没有诊断出卵巢癌。总之，大多数进行降低风险的输卵管切除术的BRCA突变携带者对他们的决定感到满意，并且输卵管切除术后的风险感知较低，尽管一些较老的变异携带者并未计划将来的卵巢切除术。在BRCA突变携带者中行输卵管切除术和延迟输卵管切除术仍在研究中，应在临床试验中进行，以防止在证明安全性之前引入创新。