In high-risk individuals participating in a pancreatic cancer surveillance program, worrisome features warrant for intensified surveillance or, occasionally, surgery. Our objectives were to determine the patient-reported burden of intensified surveillance and/or surgery, and to assess post-operative quality of life and opinion of surgery. Participants in our pancreatic cancer surveillance program completed questionnaires including the Cancer Worry Scale (CWS) and the Hospital Anxiety and Depression Scale (HADS). For individuals who underwent intensified surveillance, questionnaires before, during, and ≥ 3 weeks after were analyzed. In addition, subjects who underwent intensified surveillance in the past 3 years or underwent surgery at any time, were invited for an interview, that included the Short-Form 12 (SF-12). A total of 31 high-risk individuals were studied. During the intensified surveillance period, median CWS scores were higher (14, IQR 7), as compared to before (12, IQR 9, P = 0.007) and after (11, IQR 7, P = 0.014), but eventually returned back to baseline (P = 0.823). Median HADS scores were low: 5 (IQR 6) for anxiety and 3 (IQR 5) for depression, and they were unaffected by the intensified surveillance period. Of the 10 operated patients, 1 (10%) developed diabetes and 7 (70%) pancreatic exocrine insufficiency. The interviews yielded median quality-of-life scores comparable to the general population. Also, after surgery, patients’ attitudes towards surveillance were unchanged (5/10, 50%) or became more positive (4/10, 40%). Although patients were aware of the (sometimes benign) pathological outcome, when asked if surgery had been justified, only 20% (2/10) disagreed, and all would again have chosen to undergo surgery. In conclusion, in individuals at high risk for pancreatic cancer, intensified surveillance temporarily increased cancer worries, without affecting general anxiety or depression. Although pancreatic surgery led to substantial co-morbidity, quality of life was similar to the general population, and surgery did not negatively affect the attitude towards surveillance.

中文翻译：

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患者报告的在胰腺癌监测下高危人群的强化监测和手术负担。

在参加胰腺癌监测计划的高风险个体中，令人担忧的特征需要加强监测或偶尔进行手术。我们的目标是确定患者报告的强化监视和/或手术负担，并评估术后生活质量和手术意见。我们胰腺癌监测计划的参与者填写了问卷，包括癌症忧虑量表（CWS）和医院焦虑与抑郁量表（HADS）。对于接受加强监视的个人，分析了之前，之中和之后≥3周的问卷。此外，还邀请了在过去3年中接受过强化监视或随时进行手术的受试者进行访谈，其中包括12号简表（SF-12）。总共研究了31位高危人群。在强化监视期间，中位数CWS分数（之前为14，IQR 7）高于以前（之前为12，IQR 9）P  = 0.007）和之后（11，IQR 7，P  = 0.014），但最终返回到基线（P = 0.823）。HADS的中位数较低：焦虑的得分为5（IQR 6），抑郁的得分为3（IQR 5），并且不受强化监测期的影响。在10例手术患者中，1例（10％）患上糖尿病，7例（70％）胰腺外分泌功能不全。访谈得出的生活质量中位数得分与普通人群相当。此外，手术后，患者对监视的态度没有改变（5 / 10，50％）或变得更加积极（4 / 10，40％）。尽管患者意识到（有时是良性的）病理结果，但是当被问及手术是否合理时，只有20％（2/10）的患者不同意，所有患者都将再次选择接受手术。总之，在胰腺癌高危人群中，加强监护可以暂时增加对癌症的担忧，而又不影响全身性焦虑或抑郁。