Ferulic acid (FA) is a natural antioxidant with limited absorption when conjugated with biomolecules but whose free form is readily absorbed in the stomach and, to a lesser extent, in the ileum. The latter suffers from inflammation and oxidative stress, so a novel strategy for the delivery of FA in this compartment of the gastrointestinal tract was developed. Using the neutral un-functionalized resin Lewatit® VP OC 1064 MD PH, under optimized conditions, a loading of 144 mg FA/g of dry resin was obtained. By means of an in vitro simulated digestion, an average release of 32 mg FA/g of dry loaded resin (recovery of 22%) was observed in intestinal conditions. The incorporation/release of FA onto/from the resin was confirmed by ATR-FTIR spectroscopy and by HPLC-DAD. This work showed that the free form of FA can effectively be delivered in the small intestine, after immobilization in solid matrices.

中文翻译：

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在模拟胃肠道条件下释放吸附的阿魏酸

阿魏酸（FA）是天然抗氧化剂，与生物分子结合时吸收有限，但其游离形式很容易在胃中吸收，而在回肠中吸收程度较小。后者患有炎症和氧化应激，因此开发了在胃肠道的该隔室中递送FA的新策略。使用中性未官能化的VP OC 1064 MD PH树脂，在优化条件下，可得到144 mg FA / g干燥树脂的负载量。通过体外模拟消化，在肠道条件下观察到平均释放32 mg FA / g干负载树脂（回收率为22％）。通过ATR-FTIR光谱法和通过HPLC-DAD证实FA在树脂上的结合/释放。