Impaired social facilitation was reported in autism spectrum disorder (ASD) children. However, behavioral analysis methods of social facilitation for ASD model have not been reported. We developed a novel breeding home cage for social facilitation. Voluntary exercise of more social C57BL/6 J mice was significantly increased in the presence of observer mouse compared to that in the absence of observer mouse. In contrast, the presence of observer mouse did not affect voluntary exercise of less social BALB/cCrSlc mice. These suggest that BALB/cCrSlc mice, a mouse model of ASD, exhibited impaired social facilitation. Our method would provide novel clues for ASD pathophysiology.

中文翻译：

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BALB/cCrSlc 小鼠自愿运动的社会促进受损，建议作为自闭症谱系障碍模型

据报道，自闭症谱系障碍 (ASD) 儿童的社交便利性受损。然而，ASD模型的社会促进行为分析方法尚未见报道。我们开发了一种新颖的繁殖家庭笼，以促进社会发展。与没有观察者小鼠的情况相比，在观察者小鼠存在的情况下，更多社会 C57BL/6 J 小鼠的自愿运动显着增加。相比之下，观察者小鼠的存在不影响社会性较低的 BALB/cCrSlc 小鼠的自愿运动。这些表明 BALB/cCrSlc 小鼠（一种 ASD 小鼠模型）表现出社交便利性受损。我们的方法将为 ASD 病理生理学提供新的线索。