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The long-term residual effects of low-magnitude mechanical stimulation therapy on skeletal health
Journal of Biological Engineering ( IF 5.6 ) Pub Date : 2020-03-14 , DOI: 10.1186/s13036-020-0232-x
Kyle A Bodnyk 1 , Kyle S Kuchynsky 1 , Megan Balgemann 1 , Brooke Stephens 1 , Richard T Hart 1
Affiliation  

Low-magnitude mechanical stimulation (LMMS) may improve skeletal health. The objective of this research was to investigate the long-term residual effects of LMMS on bone health. 10-week old female mice were given LMMS for 8 weeks; SHAM did not receive LMMS. Some groups remained on study for an additional 8 or 16 weeks post treatment (N = 17). Epiphyseal trabecular mineralizing surface to bone surface ratio (MS/BS) and bone formation rate (BFR/BS) were significantly greater in the LMMS group compared to the SHAM group at 8 weeks by 92 and 128% respectively. Mineral apposition rate (MAR) was significantly greater in the LMMS group 16 weeks post treatment by 14%. Metaphyseal trabecular bone mineral density (BMD) increased by 18%, bone volume tissue volume ratio (BV/TV) increased by 37%, and trabecular thickness (Tb.Th.) increased by 10% with LMMS at 8 weeks post treatment. Significant effects 16 weeks post treatment were maintained for BV/TV and Tb.Th. The middle-cortical region bone volume (BV) increased by 4% and cortical thickness increased by 3% with 8-week LMMS. LMMS improves bone morphological parameters immediately after and in some cases long-term post LMMS. Results from this work will be helpful in developing treatment strategies to increase bone health in younger individuals.

中文翻译:

低强度机械刺激疗法对骨骼健康的长期残余影响

低强度机械刺激 (LMMS) 可以改善骨骼健康。本研究的目的是调查 LMMS 对骨骼健康的长期残留影响。10周龄雌性小鼠给予LMMS 8周;SHAM 没有收到 LMMS。一些组在治疗后继续研究 8 或 16 周(N = 17)。在 8 周时,与 SHAM 组相比,LMMS 组的骨骺小梁矿化表面与骨表面比率 (MS/BS) 和骨形成率 (BFR/BS) 分别显着提高 92% 和 128%。LMMS 组在治疗后 16 周的矿物质沉积率 (MAR) 显着增加 14%。干骺端骨小梁密度(BMD)增加 18%,骨体积组织体积比(BV/TV)增加 37%,骨小梁厚度(Tb.Th. ) 在治疗后 8 周使用 LMMS 增加 10%。BV/TV 和 Tb.Th 在治疗后 16 周保持显着效果。8 周的 LMMS 中皮质区域骨体积 (BV) 增加了 4%,皮质厚度增加了 3%。LMMS 可在 LMMS 后立即改善骨形态参数,在某些情况下可长期改善骨形态参数。这项工作的结果将有助于制定治疗策略以增加年轻人的骨骼健康。
更新日期:2020-04-22
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