Colour-sidedness is a striking coat colour pattern found in a number of cattle breeds, typically characterised by a white stripe that extends along the back, head and belly of the animal. This dominant phenotype is caused by two related translocations (Cs6 and Cs29 ) that alter a region downstream of the KIT gene. Gloucester cattle are native to the UK and are known for an unusual colour-sided pattern that does not extend to the head. We carried out whole-genome sequencing of two Gloucester bulls as well as colour-sided Irish Moiled, British White and Pustertaler Sprinzen for comparison. We found that the Gloucester cattle also have a complex structural variant downstream of KIT, which overlaps the regions involved in Cs6 and Cs29 . All three alleles potentially disrupt a number of putative regulatory elements downstream of KIT. These results complement and expand on the recently published work focused on the Pinzgauer breed from Austria, a carrier of the same colour-sided pattern as seen in Gloucester cattle.

中文翻译：

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格洛斯特牛的颜色偏多与影响KIT下游调控元件的复杂结构变异有关。

彩色面是在许多牛品种中发现的醒目的大衣颜色图案，通常特征是沿着动物的背部，头部和腹部延伸的白色条纹。该显性表型是由改变KIT基因下游区域的两个相关易位（Cs6和Cs29）引起的。格洛斯特（Gloucester）牛原产于英国，并以不延伸到头部的不寻常的彩色侧面图案而闻名。为了比较，我们对两只格洛斯特公牛进行了全基因组测序，并对有色面的爱尔兰摩尔人，英属怀特和Pustertaler Sprinzen进行了比较。我们发现格洛斯特牛在KIT下游也具有复杂的结构变异，与Cs6和Cs29涉及的区域重叠。所有这三个等位基因都可能破坏KIT下游的许多假定调控元件。