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Characterization of the colonic response to bisacodyl in children with treatment-refractory constipation.
Neurogastroenterology & Motility ( IF 3.5 ) Pub Date : 2020-04-13 , DOI: 10.1111/nmo.13851
Paul T Heitmann 1 , Lukasz Wiklendt 1 , Nikhil Thapar 2 , Osvaldo Borrelli 2 , Carlo Di Lorenzo 3 , Desalegn T Yacob 3 , Desiree F Baaleman 3 , Mana H Vriesman 3, 4 , Samuel Nurko 5 , Khalil El-Chammas 6 , Ajay Kaul 6 , Marc A Benninga 4 , Ilan J N Koppen 4 , David A Wattchow 1 , Simon J H Brookes 1 , Phil G Dinning 1
Affiliation  

Colonic manometry with intraluminal bisacodyl infusion can be used to assess colonic neuromuscular function in children with treatment‐refractory constipation. If bisacodyl does not induce high‐amplitude propagating contractions (HAPCs), this can be an indication for surgical intervention. A detailed characterization of the colonic response to intraluminal bisacodyl in children with constipation may help to inform clinical interpretation of colonic manometry studies.

中文翻译:

治疗难治性便秘患儿对比沙可啶的结肠反应特征。

结肠腔测压结合腔内比索可啶输注可用于评估难治性便秘患儿的结肠神经肌肉功能。如果比沙可啶不引起高幅度传播收缩(HAPC),则可能是手术干预的指征。便秘儿童结肠对腔内比沙可啶的结肠反应的详细表征可能有助于指导结肠测压研究的临床解释。
更新日期:2020-04-13
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