Background The present study evaluates the possible prognostic benefits of 7 T susceptibility weighted imaging (SWI) of traumatic cerebral microbleeds (TMBs) over 3 T SWI to predict the acute clinical state and subjective impairments, including health-related quality of life (HRQOL), after closed head injury (CHI). Methods The study group comprised 10 participants with known TMBs All subjects underwent 3 T magnetic resonance imaging (MRI) and 7 T MRI, respectively. Location and count of TMBs were independently evaluated by two neuroradiologists. The initial Glasgow Coma Scale (GCS), the duration of coma and further clinical data were taken from the patients records. HRQOL was assessed by means of a questionnaire. Memory complaints and neurological symptoms were inquired at the time of the MRI examinations. Results SWI revealed a total of 485 TMBs at 3 T, 584 TMBs at 7 T with similar spatial resolution, and 684 TMBs at 7 T with a factor of 10 higher spatial resolution. The TMBs depicted by 7 T high-resolution SWI were correlated with the duration of coma (Spearman's rho of 0.77). The corresponding association with TMBs in 3 T MRI SWI showed a Spearman's rho of 0.71. The initial GCS score and TMBs correlated with a Spearman's rho of -0.35 at 3 T SWI MRI and a rho of -0.33 at 7 T high-resolution SWI, respectively. The physical aspect of HRQOL correlated substantially with the count of TMBs (rho = 0.44 for 3 T SWI and rho = 0.35 for both 7 T SWI sequences, respectively). Conclusions The number of TMBs showed a substantial association with indicators of the acute clinical state and chronic neurobehavioral parameters after CHI, but there was no additional advantage of 7 T MRI. These preliminary findings warrant a larger prospective study for the future.

中文翻译：

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7 T 超高场 MRI 对创伤性脑微出血的更高敏感性：对患者的急性状态和以后的生活质量是否具有临床意义？

背景 本研究评估了创伤性脑微出血 (TMBs) 的 7 T 磁敏感加权成像 (SWI) 超过 3 T SWI 预测急性临床状态和主观损伤的可能预后益处，包括与健康相关的生活质量 (HRQOL)、闭合性头部受伤 (CHI) 后。方法 研究组由 10 名已知 TMB 的参与者组成，所有受试者分别接受了 3 T 磁共振成像 (MRI) 和 7 T MRI。TMB 的位置和计数由两名神经放射科医生独立评估。最初的格拉斯哥昏迷量表 (GCS)、昏迷持续时间和进一步的临床数据取自患者记录。HRQOL 通过问卷进行评估。在核磁共振检查时询问记忆问题和神经系统症状。结果 SWI 显示在 3 T 时共有 485 个 TMB，在 7 T 时有 584 个 TMB，具有相似的空间分辨率，在 7 T 时有 684 个 TMB，空间分辨率高 10 倍。7 T 高分辨率 SWI 描绘的 TMB 与昏迷持续时间相关（Spearman rho 为 0.77）。在 3 T MRI SWI 中与 TMB 的相应关联显示 Spearman rho 为 0.71。初始 GCS 评分和 TMB 分别与 3 T SWI MRI 下 -0.35 的 Spearman rho 和 7 T 高分辨率 SWI 下 -0.33 的 rho 相关。HRQOL 的物理方面与 TMB 计数显着相关（3 T SWI 的 rho = 0.44 和 7 T SWI 序列的 rho = 0.35，分别）。结论 TMBs 的数量与 CHI 后的急性临床状态和慢性神经行为参数指标显着相关，但 7 T MRI 没有额外的优势。这些初步发现值得对未来进行更大规模的前瞻性研究。