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Jatrophane and rearranged jatrophane-type diterpenes: biogenesis, structure, isolation, biological activity and SARs (1984-2019).
Phytochemistry Reviews ( IF 7.7 ) Pub Date : 2020-04-13 , DOI: 10.1007/s11101-020-09667-8
Maryam Fattahian 1 , Mustafa Ghanadian 1, 2 , Zulfiqar Ali 2 , Ikhlas A Khan 2
Affiliation  

Diterpene compounds specially macrocyclic ones comprising jatrophane, lathyrane, terracinolide, ingenane, pepluane, paraliane, and segetane skeletons occurring in plants of the Euphorbiaceae family are of considerable interest in the context of natural product drug discovery programs. They possess diverse complex skeletons and a broad spectrum of therapeutically relevant biological activities including anti-inflammatory, anti-chikungunya virus, anti-HIV, cytotoxic, and multidrug resistance-reversing activities as well as curative effects on thrombotic diseases. Among macrocyclic diterpenes of Euphorbia, the discovery of jatrophane and modified jatrophane diterpenes with a wide range of structurally unique polyoxygenated polycyclic derivatives and as a new class of powerful inhibitors of P-glycoprotein has opened new frontiers for research studies on this genus. In this review, an attempt has been made to give in-depth coverage of the articles on the naturally occurring jatrophanes and rearranged jatrophane-type diterpenes isolated from species belonging to the Euphorbiaceae family published from 1984 to March 2019, with emphasis on the biogenesis, isolation methods, structure, biological activity, and structure-activity relationship.

中文翻译:

麻风树烷和重排的麻风树烷型二萜:生物发生、结构、分离、生物活性和 SAR(1984-2019)。

在大戟科植物中出现的二萜化合物,特别是大环化合物,包括 jatrophane、lathyrane、terracinolide、ingenane、pepluane、paraliane 和 segetane 骨架,在天然产物药物发现计划的背景下具有相当大的兴趣。它们具有多种复杂的骨架和广泛的治疗相关生物活性,包括抗炎、抗基孔肯雅病毒、抗艾滋病毒、细胞毒性和多药耐药逆转活性以及对血栓性疾病的疗效。在大戟属的大环二萜中,麻风树烷和修饰的麻风树烷二萜的发现,具有广泛的结构独特的多氧多环衍生物,并作为一类新的 P-糖蛋白的强效抑制剂,为该属的研究开辟了新的前沿。在这篇综述中,试图深入报道 1984 年至 2019 年 3 月发表的从大戟科物种中分离的天然存在的麻风树烷和重排麻风树烷型二萜的文章,重点是生物发生,分离方法、结构、生物活性和构效关系。
更新日期:2020-04-22
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