The utilization of green syntheses is important for reducing environmental pollution. Many synthetic approaches have been developed for the synthesis of isatin-thiazolidine hybrids. However, none of these methods directly address a green methodology for the synthesis of this key organic scaffold. This work deals with the synthesis of isatin-thiazolidine hybrids using graphene oxide (GO) catalyst in deep eutectic solvent (DES) as a green media. Synthesized compounds were evaluated for in-vitro antibacterial, anticancer and cytotoxic activities. The tested compounds exhibited more antibacterial activity against Gram-positive bacteria than Gram-negative bacteria. The compounds were observed to contain electron-withdrawing groups which displayed more bacterial inhibition. In summary, the current study reports that eco-friendly graphene oxide together with deep eutectic solvent catalyzed the synthesis of isatin-thiazolidine hybrids, whereby a high product yield was achieved in a short space of time. Although, newly synthesized compounds could not produce efficient biological activity, cytotoxicity instead.

绿色合成物的使用对于减少环境污染很重要。已经开发出许多合成方法来合成伊斯汀-噻唑烷杂化物。然而，这些方法均未直接解决用于合成该关键有机支架的绿色方法。这项工作涉及在深共熔溶剂（DES）中将氧化石墨烯（GO）催化剂用作绿色介质，合成isatin-thiazolidine杂化物的方法。对合成的化合物进行体外评估抗菌，抗癌和细胞毒活性。所测试的化合物对革兰氏阳性菌的抑制作用要强于革兰氏阴性菌。观察到该化合物含有吸电子基团，该吸电子基团显示出更多的细菌抑制作用。总而言之，本研究报告表明，环保型氧化石墨烯与深共熔溶剂一起催化了isatin-thiazolidine杂化体的合成，从而在短时间内获得了较高的产品收率。尽管新合成的化合物不能产生有效的生物活性，但可以产生细胞毒性。