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Effects of florfenicol on growth, photosynthesis and antioxidant system of the non-target organism Isochrysis galbana.
Comparative Biochemistry and Physiology C: Toxicology & Pharmacology ( IF 3.9 ) Pub Date : 2020-04-12 , DOI: 10.1016/j.cbpc.2020.108764 Yingqi Zhang 1 , Xianyu Zhang 1 , Rui Guo 1 , Qian Zhang 1 , Xupeng Cao 2 , Mehjabin Suranjana 3 , Ying Liu 1
Comparative Biochemistry and Physiology C: Toxicology & Pharmacology ( IF 3.9 ) Pub Date : 2020-04-12 , DOI: 10.1016/j.cbpc.2020.108764 Yingqi Zhang 1 , Xianyu Zhang 1 , Rui Guo 1 , Qian Zhang 1 , Xupeng Cao 2 , Mehjabin Suranjana 3 , Ying Liu 1
Affiliation
Florfenicol (FFC) is one of the most universally used antibiotics in aquaculture, which is substitute for chloramphenicol extensively, while the massive residues in aquatic environment were assumed to threaten the non-target organisms. Present research investigated the effects of florfenicol on growth, chlorophyll content, photosynthesis, and antioxidant ability of Isochrysis galbana. The results showed that FFC at 0.001-1 mg/L stimulated the growth of I. galbana and increased the content of chlorophyll. In addition, photosynthesis of I. galbana was inhibited and the photosynthetic parameters were uplifted with the increased exposure duration and FFC concentration. Furthermore, superoxide dismutase (SOD), catalase (CAT) activity significantly dropped at 0.01-20 mg/L FFC, while the contents of malondialdehyde (MDA), glutathione (GSH) and reactive oxygen species (ROS) increased after 72 h exposure, indicating that FFC at high concentrations caused a serious oxidative stress on algae. The simultaneous increase of ROS disrupted the equilibration between oxidants and antioxidant systems. Under the high concentration of FFC, the excessive of ROS was generated in algae which affected the membrane permeability and further decreased the cell biomass. Present study showed that acute exposure (72 h) at the environmental relevant concentration (0.01 mg/L) cannot induce the physiological dysfunction of the microalgae I. galbana, but the feeding concentration (20 mg/L) can. Additionally, this study hinted the possible negative impacts on ecosystems with the chronic exposure even at low FFC concentration or with the uncontrolled use of FFC.
中文翻译:
氟苯尼考对非靶标生物等鞭藻生长,光合作用和抗氧化系统的影响。
氟苯尼考(FFC)是水产养殖中使用最广泛的抗生素之一,可广泛替代氯霉素,而假定水生环境中的大量残留物会威胁非目标生物。目前的研究调查了氟苯尼考对球墨鱼的生长,叶绿素含量,光合作用和抗氧化能力的影响。结果表明,FFC在0.001-1 mg / L时刺激了长白象豆的生长并增加了叶绿素的含量。此外,随着暴露持续时间和FFC浓度的增加,银杏的光合作用受到抑制,光合参数得到提高。此外,在0.01-20 mg / L FFC下,超氧化物歧化酶(SOD),过氧化氢酶(CAT)活性显着下降,而丙二醛(MDA),暴露72小时后谷胱甘肽(GSH)和活性氧(ROS)增加,表明高浓度的FFC对藻类造成严重的氧化应激。ROS的同时增加破坏了氧化剂和抗氧化剂系统之间的平衡。在高浓度的FFC下,藻类中会产生过量的ROS,从而影响膜的通透性并进一步降低细胞的生物量。目前的研究表明,在与环境有关的浓度(0.01 mg / L)下的急性暴露(72 h)不能诱发微藻(I. galbana)的生理功能障碍,但对饲料浓度(20 mg / L)却可以。此外,这项研究还表明,即使在低FFC浓度或无控制地使用FFC的情况下,长期暴露也可能对生态系统产生负面影响。
更新日期:2020-04-20
中文翻译:
氟苯尼考对非靶标生物等鞭藻生长,光合作用和抗氧化系统的影响。
氟苯尼考(FFC)是水产养殖中使用最广泛的抗生素之一,可广泛替代氯霉素,而假定水生环境中的大量残留物会威胁非目标生物。目前的研究调查了氟苯尼考对球墨鱼的生长,叶绿素含量,光合作用和抗氧化能力的影响。结果表明,FFC在0.001-1 mg / L时刺激了长白象豆的生长并增加了叶绿素的含量。此外,随着暴露持续时间和FFC浓度的增加,银杏的光合作用受到抑制,光合参数得到提高。此外,在0.01-20 mg / L FFC下,超氧化物歧化酶(SOD),过氧化氢酶(CAT)活性显着下降,而丙二醛(MDA),暴露72小时后谷胱甘肽(GSH)和活性氧(ROS)增加,表明高浓度的FFC对藻类造成严重的氧化应激。ROS的同时增加破坏了氧化剂和抗氧化剂系统之间的平衡。在高浓度的FFC下,藻类中会产生过量的ROS,从而影响膜的通透性并进一步降低细胞的生物量。目前的研究表明,在与环境有关的浓度(0.01 mg / L)下的急性暴露(72 h)不能诱发微藻(I. galbana)的生理功能障碍,但对饲料浓度(20 mg / L)却可以。此外,这项研究还表明,即使在低FFC浓度或无控制地使用FFC的情况下,长期暴露也可能对生态系统产生负面影响。