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Plant Aromatic Prenyltransferases: Tools for Microbial Cell Factories.
Trends in Biotechnology ( IF 17.3 ) Pub Date : 2020-04-13 , DOI: 10.1016/j.tibtech.2020.02.006
Wouter J C de Bruijn 1 , Mark Levisson 2 , Jules Beekwilder 3 , Willem J H van Berkel 1 , Jean-Paul Vincken 1
Affiliation  

In plants, prenylation of aromatic compounds, such as (iso)flavonoids and stilbenoids, by membrane-bound prenyltransferases (PTs), is an essential step in the biosynthesis of many bioactive compounds. Prenylated aromatic compounds have various health-beneficial properties that are interesting for industrial applications, but their exploitation is limited due to their low abundance in nature. Harnessing plant aromatic PTs for prenylation in microbial cell factories may be a sustainable and economically viable alternative. Limitations in prenylated aromatic compound production have been identified, including availability of prenyl donor substrate. In this review, we summarize the current knowledge about plant aromatic PTs and discuss promising strategies towards the optimized production of prenylated aromatic compounds by microbial cell factories.



中文翻译:

植物芳香异戊二烯基转移酶:微生物细胞工厂的工具。

在植物中,通过膜结合异戊二烯基转移酶(PTs)将芳香族化合物(如(异)类黄酮和类芪)异戊烯化是许多生物活性化合物生物合成中必不可少的步骤。烯丙基化的芳族化合物具有各种有益健康的特性,工业上很感兴趣,但是由于它们的低丰度,其开发受到了限制。在微生物细胞工厂中利用植物芳香族PT进行异戊二烯化可能是一种可持续且在经济上可行的选择。已经确定了烯丙基化芳族化合物生产的限制,包括异戊二烯供体底物的可用性。在这篇综述中,我们总结了有关植物芳香族PT的当前知识,并讨论了通过微生物细胞工厂优化生产烯丙基化芳香族化合物的有前途的策略。

更新日期:2020-04-13
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