HLA-G has been widely implicated in advanced cancers through different pathways of immunosuppression allowing tumor escape. Contrarily, HLA-E has a controversial role in the tumor escape from the immune system. IDO catabolic enzyme is known to be up-regulated in many tumors types allowing their immune escape. Based on these considerations, we investigated the expression of HLA-G, HLA-E and IDO molecules in endometrial cancer (EC) and their association with prognostic clinicopathologic parameters. Their expression were checked in tumoral and adjacent endometrial tissues. Both HLA-G and IDO immunostaining were significantly increased in EC tissues compared to normal residual endometrial glands (Mann Whitney U-test, p = 0.0001 and p = 0,020 respectively). However, HLA-E was highly expressed in tumoral tissues as well as in normal residual endometrial glands (respectively, 100% and 81.8%). Increased HLA-G expression levels were observed in high histological grade (grade 3), and in the non-endometrioid type 2 EC. Unexpectedly, patients with IDO Low expression had significantly impaired overall survival compared to patients with IDO High (log-rank p = 0.021). Conversely, HLA-E low expression was associated to an improved overall survival EC (log-rank p = 0.004). We concluded that, HLA-G and IDO are highly expressed in EC compared to adjacent normal endometrial tissues, that might be interesting for the EC outcome.

HLA-G已通过不同的免疫抑制途径（可能使肿瘤逃逸）广泛参与了晚期癌症。相反，HLA-E在肿瘤从免疫系统逃逸中具有争议性作用。已知IDO分解代谢酶在许多类型的肿瘤中均被上调，从而使其免疫逃逸。基于这些考虑，我们调查了子宫内膜癌（EC）中HLA-G，HLA-E和IDO分子的表达及其与预后临床病理参数的关系。检查它们在肿瘤和邻近子宫内膜组织中的表达。与正常残余子宫内膜腺相比，EC组织中的HLA-G和IDO免疫染色均显着增加（Mann Whitney U检验，p  = 0.0001和p 分别为0,020）。但是，HLA-E在肿瘤组织以及正常残留子宫内膜腺体中高表达（分别为100％和81.8％）。在高组织学级别（3级）和非子宫内膜样2型EC中观察到HLA-G表达水平增加。出乎意料的是，IDO低表达的患者与IDO高表达的患者相比，其总生存期显着受损（log-rank p  = 0.021）。相反，HLA-E低表达与总体生存EC改善有关（log-rank p  = 0.004）。我们的结论是，与邻近的正常子宫内膜组织相比，HLA-G和IDO在EC中高表达，这可能对EC结局很有意义。