Exposure to the man-made chemicals perfluorooctanoic acid (PFOA), perfluorooctane sulfonate (PFOS) and perfluorohexanesulfonate (PFHxS) is widespread. These perfluoroalkyl substances (PFASs) have been associated with androgenic endocrine-disrupting properties; however, the evidence is equivocal and few human studies have examined the association between prenatal exposure to PFASs and markers of androgenic endocrine disruption such as changes in anogenital distance (AGD). In the MIREC cohort, PFOA, PFOS and PFHxS were analyzed in first trimester maternal plasma. AGD was measured in 205 male and 196 female newborns. The change in estimate procedure was used to identify confounders by sex and AGD in multiple linear regression models. Geometric mean plasma concentrations (95% CI) for PFOA, PFOS and PFHxS were 1.71 (1.61, 1.81), 4.40 (4.18, 4.64) and 1.15 (1.06, 1.25) μg/L, respectively. A one-unit increase in natural log transformed PFOA was associated with a 1.36 mm (95% CI 0.30, 2.41) increase in anoscrotal distance, adjusting for household income, active smoking status during pregnancy and gestational age. However, when examined by quartiles, a non-monotonic pattern was observed with wide confidence intervals. No consistent patterns were observed between maternal PFAS concentrations and female AGDs. This study found no clear evidence that maternal plasma concentrations of PFOS, PFOA or PFHxS were associated with shorter infant anogenital distance in males or any change in AGD in females. Whether the positive association observed between longer anoscrotal distance and PFOA is real or would have any long-lasting effect on the reproductive health of males is unknown and needs to be investigated further.

中文翻译：

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加拿大队列中的产前全氟烷基物质和新生儿生殖器距离。

人造化学物质全氟辛酸（PFOA），全氟辛烷磺酸盐（PFOS）和全氟己烷磺酸盐（PFHxS）的暴露范围很广。这些全氟烷基物质（PFAS）与干扰雄激素的内分泌有关。然而，证据是模棱两可的，很少有人类研究检查产前暴露于PFAS的暴露与雄激素内分泌干扰标志物（如肛门生殖器距离（AGD）的改变）之间的关系。在MIREC队列中，在孕早期孕妇血浆中分析了PFOA，PFOS和PFHxS。在205名男性和196名女性新生儿中测量了AGD。估计程序的更改用于在多个线性回归模型中通过性别和AGD识别混杂因素。PFOA，PFOS和PFHxS的几何平均血浆浓度（95％CI）为1.71（1.61、1.81），4.40（4.18、4.64）和1。15（1.06，1.25）μg/ L。天然对数转化的PFOA增加1个单位，使踝部距离增加1.36毫米（95％CI 0.30，2.41），可以根据家庭收入，怀孕期间和胎龄的积极吸烟状况进行调整。但是，当用四分位数检查时，观察到的非单调模式具有宽置信区间。在母体PFAS浓度和女性AGD之间未观察到一致的模式。这项研究没有明确的证据表明，孕妇血浆PFOS，PFOA或PFHxS的浓度与男性较短的婴儿肛门生殖器距离或女性的AGD变化有关。