Neuron-Glial2 (NG2) expressing cells are described as the oligodendrocyte precursor cells in the brain. This study aimed to investigate the possible involvement of NG2 cells under the methamphetamine (METH)-induced neurotoxicity and neuroprotective capacity of melatonin. The results showed that the levels of NG2 in rat brain gradually increase from postnatal day 0 to postnatal day 8 and then the lower levels of NG2 are shown in adults. In adult rats, the levels of NG2 and COX-2 in the brain were significantly increased in lipopolysaccharide treatment. Pretreatment of 10 mg/kg melatonin prior to treating with METH was able to reduce an increase in the levels of NG2 and activation in astrocyte and microglia. These findings would extend the contribution of NG2 expressing cells in the adult brain during pathological conditions such as neuroinflammation.

中文翻译：

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褪黑激素可避免在甲基苯丙胺毒性诱导的大鼠脑神经炎症中诱导表达神经元神经胶质2 (NG2) 的细胞

Neuron-Glial2 (NG2) 表达细胞被描述为大脑中的少突胶质细胞前体细胞。本研究旨在调查 NG2 细胞在甲基苯丙胺 (METH) 诱导的褪黑激素神经毒性和神经保护能力下的可能参与。结果表明，大鼠脑中NG2的水平从出生后第0天到出生后第8天逐渐增加，然后在成人中显示出较低水平的NG2。在成年大鼠中，脂多糖处理显着增加脑中 NG2 和 COX-2 的水平。在用 METH 处理之前预处理 10 mg/kg 褪黑激素能够减少星形胶质细胞和小胶质细胞中 NG2 和活化水平的增加。