Drosophila Larval hematopoiesis takes place at the lymph gland, where myeloid-like progenitors differentiate into Plasmatocytes and Crystal Cells, under regulation of conserved signaling pathways. It has been established that the Notch pathway plays a specific role in Crystal Cell differentiation and maintenance. In mammalian hematopoiesis, the Notch pathway has been proposed to fulfill broader functions, including Hematopoietic Stem Cell maintenance and cell fate decision in progenitors. In this work we describe different roles that Notch plays in the lymph gland. We show that Notch, activated by its ligand Serrate, expressed at the Posterior Signaling Center, is required to restrain Core Progenitor differentiation. We define a novel population of blood cell progenitors that we name Distal Progenitors, where Notch, activated by Serrate expressed in Lineage Specifying Cells at the Medullary Zone/Cortical Zone boundary, regulates a binary decision between Plasmatocyte and Crystal Cell fates. Thus, Notch plays context-specific functions in different blood cell progenitor populations of the Drosophila lymph gland.

中文翻译：

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Notch在果蝇血细胞祖细胞中的上下文特定功能。

果蝇幼虫造血发生在淋巴腺，在保守的信号传导通路的调节下，髓样样祖细胞分化为浆细胞和晶体细胞。已经确定，Notch途径在晶体细胞的分化和维持中起特定作用。在哺乳动物的造血中，已经提出了Notch途径来实现更广泛的功能，包括造血干细胞的维持和祖细胞的命运决定。在这项工作中，我们描述了Notch在淋巴腺中扮演的不同角色。我们显示Notch，由其后信号中心表达的其配体锯齿激活，是抑制核心祖细胞分化所必需的。我们定义了一个新的血细胞祖细胞群，我们将其命名为Distal Progenitors，其中Notch，由在髓质区/皮质区边界的沿袭指定细胞中表达的锯齿状蛋白激活，调节浆细胞和晶体细胞命运之间的二元决定。因此，Notch在果蝇淋巴腺的不同血细胞祖细胞群中发挥特定于上下文的功能。