Background

It is well known that febrile seizures are commonly occur in children with exanthem subitum. In this study, we compared the clinical features and backgrounds of patients with complex febrile seizures with and without primary human herpesvirus 6B infection.

Methods

Sixty-two patients were enrolled after experiencing their first febrile seizure. Primary human herpesvirus 6B infection was confirmed when human herpesvirus 6B DNA was detected and human herpesvirus 6B antibody was negative in serum obtained during the acute phase of infection. Patient age, gender, and features of seizures were evaluated between patients with and without human herpesvirus 6B infection.

Results

Thirty patients with complex febrile seizure were diagnosed with primary human herpesvirus 6B infection. Those with primary human herpesvirus 6B infection (median, 13 months; range, seven to 39 months) were significantly younger than those without primary human herpesvirus 6B infection (median, 19 months; range, 10 to 59 months) (P = 0.001), and the proportion of males was significantly higher in patients without primary human herpesvirus 6B infection (male/female, 25/7) than in those with the infection (male/female, 14/16) (P = 0.017). An interval between fever onset and seizures of more than 24 hours was significantly more common in patients with primary human herpesvirus 6B infection (15 of the 30 patients) than in those without primary HHV-6B infection (two of 32 patients) (P < 0.001).

Conclusions

A younger age at onset, a different gender ratio compared with febrile seizure due to other causes, and the length of interval between fever and seizures were features of complex febrile seizure associated human herpesvirus 6B infection. These findings may suggest a mechanism of complex febrile seizure onset different from that due to other causes.

中文翻译：

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原发性人类疱疹病毒6B感染引起的复杂性高热惊厥的临床特征。

背景

众所周知，高热惊厥通常发生在子痫前期儿童中。在这项研究中，我们比较了有或没有原发性人类疱疹病毒6B感染的复杂高热惊厥患者的临床特征和背景。

方法

首次发热性癫痫发作后纳入了62名患者。当在感染的急性阶段获得的血清中检测到人疱疹病毒6B DNA且人疱疹病毒6B抗体阴性时，证实了原发性人疱疹病毒6B感染。在有和没有人疱疹病毒6B感染的患者之间评估患者的年龄，性别和癫痫发作特征。

结果

30例复杂的高热惊厥患者被诊断为原发性人类疱疹病毒6B感染。患有原发性人类疱疹病毒6B感染的患者（中位时间为13个月；范围为7到39个月）比未发生原发性人类疱疹病毒6B感染的患者（中位时间为19个月；范围为10到59个月）要小得多（P  = 0.001），未感染原发性人类疱疹病毒6B的患者（男性/女性，25/7）中的男性比例明显高于感染者（男性/女性，14/16）（P  = 0.017）。原发性人类疱疹病毒6B感染的患者（30例中的15例）发烧至癫痫发作间隔超过24小时的比例明显高于无原发性HHV-6B感染的患者（32例中的2例）（P  <0.001）。

结论

与其他原因引起的高热惊厥相比，发病年龄更小，性别比例不同以及发烧和惊厥之间的间隔时间长是与高热惊厥相关的人类疱疹病毒6B感染的特征。这些发现可能表明复杂的高热惊厥发作的机制不同于其他原因。