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A comprehensive analysis of genome composition and codon usage patterns of emerging coronaviruses.
Virus Research ( IF 5 ) Pub Date : 2020-04-12 , DOI: 10.1016/j.virusres.2020.197976 Fernando L Tort 1 , Matías Castells 1 , Juan Cristina 2
Virus Research ( IF 5 ) Pub Date : 2020-04-12 , DOI: 10.1016/j.virusres.2020.197976 Fernando L Tort 1 , Matías Castells 1 , Juan Cristina 2
Affiliation
An outbreak of atypical pneumonia caused by a novel Betacoronavirus (βCoV), named SARS-CoV-2 has been declared a public health emergency of international concern by the World Health Organization. In order to gain insight into the emergence, evolution and adaptation of SARS-CoV-2 viruses, a comprehensive analysis of genome composition and codon usage of βCoV circulating in China was performed. A biased nucleotide composition was found for SARS-CoV-2 genome. This bias in genomic composition is reflected in its codon and amino acid usage patterns. The overall codon usage in SARS-CoV-2 is similar among themselves and slightly biased. Most of the highly frequent codons are A- and U-ending, which strongly suggests that mutational bias is the main force shaping codon usage in this virus. Significant differences in relative synonymous codon usage frequencies among SARS-CoV-2 and human cells were found. These differences are due to codon usage preferences.
更新日期：2020-04-12
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