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The evidence of SARS-CoV-2 infection on ocular surface.
The Ocular Surface ( IF 6.4 ) Pub Date : 2020-04-11 , DOI: 10.1016/j.jtos.2020.03.010
Xian Zhang 1 , Xuhui Chen 1 , Liwen Chen 1 , Chaohua Deng 1 , Xiaojing Zou 2 , Weiyong Liu 3 , Huimin Yu 1 , Bo Chen 1 , Xufang Sun 1
Affiliation  

This is a cross-sectional study of patients who received a COVID-19 diagnosis between December 30, 2019 and February 7, 2020 at Tongji Hospital. A total of 102 patients (48 Male [47%] and 54 Female [53%]) with clinical symptoms, Rt, and chest Computed Tomography (CT) abnormalities were identified with a clinical diagnosis of COVID-19. Patients had a mean [SD] gestational age of 57.63 [14.90] years. Of a total of 102 patients identified, 72 patients (36 men [50%] and 36 women [50%]; mean [SD] age, 58.68 [14.81] years) were confirmed to have COVID-19 by laboratory diagnosis with a SARS-CoV-2 RT-PCR assay. Only two patients (2.78%) with conjunctivitis were identified from 72 patients with a laboratory confirmed COVID-19. Of those two patients, SARS-CoV-2 RNA fragments were found in ocular discharges by SARS-CoV-2 RT-PCR in only one patient. Our findings suspect the incidence of SARS-CoV-2 infection through the ocular surface is extremely low, while the nosocomial infection of SARS-CoV-2 through the eyes after occupational exposure is a potential route. To lower the SARS-CoV-2 nosocomial infection, all health care professionals should wear protective goggles. The inefficient diagnostic method and the sampling time lag may contribute to the lower positive rate of conjunctival swab samples of SARS-CoV-2.



中文翻译:

眼表SARS-CoV-2感染的证据。

这是对在2019年12月30日至2020年2月7日之间在同济医院接受COVID-19诊断的患者的横断面研究。总共鉴定出102例临床症状,Rt和胸部计算机断层扫描(CT)异常的患者(48例男性[47%]和54例女性[53%]),并通过临床诊断为COVID-19。患者的[SD]平均胎龄为57.63 [14.90]年。在经实验室诊断为SARS的确诊的102例患者中,有72例(36名男性[50%]和36名女性[50%];平均[SD]年龄为58.68 [14.81]岁)被确认患有COVID-19。 -CoV-2 RT-PCR分析。在72例实验室确诊为COVID-19的患者中,只有2例(2.78%)患有结膜炎。在这两名患者中,仅一名患者通过SARS-CoV-2 RT-PCR在眼分泌物中发现了SARS-CoV-2 RNA片段。我们的研究结果怀疑通过眼表感染SARS-CoV-2的发生率极低,而职业暴露后通过眼睛进行的SARS-CoV-2医院感染是一种潜在的途径。为了降低SARS-CoV-2医院感染,所有医疗保健专业人员均应戴防护眼镜。低效的诊断方法和采样时滞可能会导致SARS-CoV-2结膜拭子样本的阳性率降低。

更新日期:2020-04-11
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