The details of the immunological microenvironment and its clinical implications for pancreatic cancer are still unclear. In this study, we obtained data from public databases, such as the Gene Expression Omnibus, the Cancer Genome Atlas Program, the International Cancer Genome Consortium Data Portal, the ArrayExpress Data Warehouse, and the cBioPortal for Cancer Genomics. We used these data to evaluate the pattern of immune cells infiltration in pancreatic ductal adenocarcinoma (PDAC) tissues. We observed that the levels of M0 macrophages and activated dendritic cells in tumor tissues were significantly higher than that in para-tumor tissues. M0 macrophages, gamma delta T cells and naive CD4 T cells were independent predictive factors of a poor outcome for PDAC patients. An immune score determined by M0 macrophages, gamma delta T cells and naive CD4 T cells could predict the survival of patients. The results of this study suggest that the infiltration of immune cells, such as M0 macrophages, may be a possible target for the treatment of PDAC. However, these findings need to be confirmed by additional studies.

中文翻译：

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胰腺导管腺癌免疫细胞浸润的情况及其临床意义。

免疫微环境的细节及其对胰腺癌的临床意义仍不清楚。在这项研究中，我们从基因表达综合，癌症基因组图谱计划，国际癌症基因组协会数据门户网站，ArrayExpress数据仓库和cBioPortal用于癌症基因组学等公共数据库中获得了数据。我们使用这些数据来评估胰腺导管腺癌（PDAC）组织中免疫细胞浸润的模式。我们观察到，肿瘤组织中M0巨噬细胞和活化的树突状细胞的水平显着高于肿瘤旁组织中的水平。M0巨噬细胞，γδT细胞和幼稚CD4 T细胞是PDAC患者预后不良的独立预测因素。由M0巨噬细胞确定的免疫评分，γT细胞和天然CD4 T细胞可以预测患者的存活率。这项研究的结果表明，免疫细胞如M0巨噬细胞的浸润可能是治疗PDAC的可能靶标。但是，这些发现需要进一步的研究证实。