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Cerebrolysin ameliorates prefrontal cortex and hippocampus neural atrophy of spontaneous hypertensive rats with hyperglycemia.
SYNAPSE ( IF 2.3 ) Pub Date : 2020-03-30 , DOI: 10.1002/syn.22156
Leonardo Aguilar-Hernández 1 , Maria de Jesús Gómez-Villalobos 2 , Gonzalo Flores 1
Affiliation  

Hyperglycemia of diabetes mellitus causes damage at the vascular level, which at the renal level represents diabetic nephropathy. In this pathology, there is arterial hypertension. In addition, several reports suggest that hyperglycemia and arterial hypertension affect interneuronal communication at the level of dendritic morphology. We studied these changes in an animal model with streptozotocin‐induced diabetes mellitus in the spontaneous hypertensive (SH) rat. Recent reports from our laboratory have demonstrated that cerebrolysin (CBL), a preparation of neuropeptides with protective and repairing properties, reduces dendritic deterioration in both pathologies, in separate studies. In the present study, we evaluated the effect of CBL using the animal model with hyperglycemia and arterial hypertension and assessed the dendritic morphology using a Golgi‐Cox staining procedure. Our results suggest that CBL ameliorated the reduction in the number of dendritic spines in the PFC and hippocampus caused by hyperglycemia in the SH rat. In addition, CBL also increased distal dendritic length in the PFC and hippocampus in hyperglycemic SH rats. Consequently, the CBL could be a therapeutic tool used to reduce the damage at the level of dendritic communication present in both pathologies.

中文翻译:

脑活素可改善自发性高血压伴高血糖大鼠的前额叶皮层和海马神经萎缩。

糖尿病的高血糖引起血管水平的损伤,在肾脏水平代表糖尿病肾病。在这种病理中,存在动脉高血压。此外,一些报告表明高血糖和动脉高血压会影响树突形态水平的神经元间通讯。我们在自发性高血压 (SH) 大鼠的链脲佐菌素诱导的糖尿病动物模型中研究了这些变化。我们实验室最近的报告表明,脑活素 (CBL),一种具有保护和修复特性的神经肽制剂,在单独的研究中减少了两种病理的树突状恶化。在目前的研究中,我们使用高血糖和动脉高血压的动物模型评估了 CBL 的效果,并使用 Golgi-Cox 染色程序评估了树突形态。我们的结果表明,CBL 改善了 SH 大鼠由高血糖引起的 PFC 和海马中树突棘数量的减少。此外,CBL 还增加了高血糖 SH 大鼠 PFC 和海马的远端树突长度。因此,CBL 可能是一种治疗工具,用于减少两种病理中存在的树突通讯水平的损伤。CBL 还增加了高血糖 SH 大鼠 PFC 和海马的远端树突长度。因此,CBL 可能是一种治疗工具,用于减少两种病理中存在的树突通讯水平的损伤。CBL 还增加了高血糖 SH 大鼠 PFC 和海马的远端树突长度。因此,CBL 可能是一种治疗工具,用于减少两种病理中存在的树突通讯水平的损伤。
更新日期:2020-03-30
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