Monocytes are important cells of the innate system. They are a heterogeneous type of cells consisting of phenotypically and functionally distinct subpopulations, which play a specific role in the control, development and escalation of the immunological processes. Based on the expression of superficial CD14 and CD16 in flow cytometry, they can be divided into three subsets: classical, intermediate and non‐classical. Variation in the levels of human monocyte subsets in the blood can be observed in patients in numerous pathological states, such as infections, cardiovascular and inflammatory diseases, cancer and autoimmune diseases. The aim of this review is to summarize current knowledge of human monocyte subsets and their significance in homeostasis and in pathological conditions.

中文翻译：

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人类单核细胞亚群在健康和疾病中的模式。

单核细胞是先天系统的重要细胞。它们是细胞的异质性类型，由表型和功能上不同的亚群组成，这些亚群在免疫过程的控制，发展和升级中起特定作用。根据流式细胞术中表面CD14和CD16的表达，它们可以分为三个子集：经典，中级和非经典。可以在处于许多病理状态的患者中观察到血液中人单核细胞亚群水平的变化，例如感染，心血管和炎性疾病，癌症和自身免疫性疾病。这篇综述的目的是总结人类单核细胞亚群的当前知识及其在稳态和病理状况中的意义。