In humans and rodents, the entorhinal cortical (EC)-hippocampal (HPC) circuit is crucial for the formation and recall of memory, preserving both spatial information and temporal information about the occurrence of past events. Both modeling and experimental studies have revealed circuits within this network that play crucial roles in encoding space and context. However, our understanding about the time-related aspects of memory is just beginning to be understood. In this review, we first describe updates regarding recent anatomical discoveries for the EC-HPC network, as several important neural circuits critical for memory formation have been discovered by newly developed neural tracing technologies. Second, we examine the complementary roles of multiple medial entorhinal cortical inputs, including newly discovered circuits, into the hippocampus for the temporal and spatial aspects of memory. Finally, we will discuss how temporal and contextual memory information is integrated in HPC cornu ammonis 1 cells. We provide new insights into the neural circuit mechanisms for anatomical and functional segregation and integration of the temporal and spatial aspects of memory encoding in the EC-HPC networks.

中文翻译：

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不同的内侧内嗅皮层输入到海马体在时间和上下文记忆的形成和整合中的互补作用（系统神经科学）

在人类和啮齿动物中，内嗅皮层 (EC)-海马 (HPC) 回路对于记忆的形成和回忆至关重要，可保留有关过去事件发生的空间信息和时间信息。建模和实验研究都揭示了该网络中的电路，它们在编码空间和上下文中起着至关重要的作用。然而，我们对记忆的时间相关方面的理解才刚刚开始被理解。在这篇综述中，我们首先描述了关于 EC-HPC 网络最近解剖学发现的更新，因为新开发的神经追踪技术已经发现了几个对记忆形成至关重要的重要神经回路。其次，我们检查了多个内侧内嗅皮层输入的互补作用，包括新发现的回路，进入海马体的时间和空间方面的记忆。最后，我们将讨论时间和上下文记忆信息是如何整合到 HPCcornu ammonis 1 细胞中的。我们提供了对 EC-HPC 网络中记忆编码的时间和空间方面的解剖和功能分离和整合的神经回路机制的新见解。