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Beta human papillomaviruses infection and skin carcinogenesis.
Reviews in Medical Virology ( IF 11.1 ) Pub Date : 2020-03-30 , DOI: 10.1002/rmv.2104
Luigia Bandolin 1 , Daniele Borsetto 2 , Jonathan Fussey 3 , Maria Cristina Da Mosto 1 , Piero Nicolai 1 , Anna Menegaldo 1 , Luca Calabrese 4 , Massimo Tommasino 5 , Paolo Boscolo-Rizzo 1
Affiliation  

During the last decade, the worldwide incidence of keratinocyte carcinomas (KC) has increased significantly. They are now the most common malignancy, representing approximately 30% of all cancers. The role of ultraviolet (UV) radiation as a major environmental risk factor for skin cancers is well recognized. The aim of this review is to analyse the current understanding of the nature of beta‐human papillomavirus (HPV) and its association with KC and explore the implications for the management and prevention of these cancers. A comprehensive review of the literature on beta‐HPV and its association with KC was undertaken, the results reported in the form of a narrative review. A subgroup of HPV that infects the mucosal epithelia of the genital tract has been firmly associated with carcinogenesis. In addition, some HPV types with cutaneous tropism have been proposed to cooperate with UV in the development of KC. The first evidence for this association was reported in 1922 in patients with epidermodysplasia verruciformis (EV). Since then, epidemiological studies have highlighted the higher risk of skin cancer in patients with EV and certain cutaneous HPV types, and in vitro studies have elucidated molecular mechanisms and transforming properties of beta‐HPV. Furthermore, in vivo research conducted on transgenic mice models has shown the possible role of beta‐HPV in cutaneous carcinogenesis as a co‐factor with UV radiation and immunosuppression. There is good evidence supporting the role of beta‐HPV in the oncogenesis of KC. The high prevalence of beta‐HPV in human skin and the worldwide burden of KC makes the search for an effective vaccine relevant and worthwhile.

中文翻译:

β人乳头瘤病毒感染和皮肤癌变。

在过去十年中,全球角化细胞癌 (KC) 的发病率显着增加。它们现在是最常见的恶性肿瘤,约占所有癌症的 30%。众所周知,紫外线 (UV) 辐射是导致皮肤癌的主要环境风险因素。本综述的目的是分析目前对 β 型人乳头瘤病毒 (HPV) 的性质及其与 KC 的关联的理解,并探讨对这些癌症的管理和预防的影响。对有关 β-HPV 及其与 KC 关联的文献进行了全面审查,结果以叙述性审查的形式报告。感染生殖道粘膜上皮的 HPV 亚群与致癌作用密切相关。此外,一些具有皮肤趋向性的HPV类型已被提出与UV合作发展KC。这种关联的第一个证据是在 1922 年在疣状表皮发育不良 (EV) 患者中报道的。此后,流行病学研究强调了 EV 和某些皮肤 HPV 类型患者患皮肤癌的风险较高,体外研究阐明了 β-HPV 的分子机制和转化特性。此外,对转基因小鼠模型进行的体内研究表明,β-HPV 作为紫外线辐射和免疫抑制的辅助因子可能在皮肤癌发生中发挥作用。有充分的证据支持 β-HPV 在 KC 的肿瘤发生中的作用。
更新日期:2020-03-30
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