Imidacloprid, a systemic chloro–nicotinyl insecticide belong to neonicotinoid insecticides. In this study 120 rats were divided into four groups, the first group used as a control group, the second group was administered imidacloprid at a dose of 22.5 mg/kg b.w. for 4, 8, and 12 weeks. The third group was treated with olive oil (OLO) in a dose of 10 ml/kg body weight for 2 weeks before the oral dose of imidacloprid for 4, 8, and 12 weeks. The fourth group was given OLO in a dose of 10 ml/kg b.w. for 2 weeks after exposure to imidacloprid for 4, 8, and 12 weeks. Bone marrow was collected for micronucleus and chromosomal aberrations assays. The results revealed that imidacloprid induced a mutagenic effect in the 8^th and 12^th weeks of exposure and OLO decreased the mutagenic effect of imidacloprid in albino rats but not completely revert them to normal.

中文翻译：

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吡虫啉杀虫剂的致突变作用：橄榄油暴露前后的改善作用。

吡虫啉是一种系统性的氯“烟碱”杀虫剂，属于新烟碱类杀虫剂。在这项研究中，将120只大鼠分为四组，第一组用作对照组，第二组给予吡虫啉22.5 mg / kg bw，持续4、8和12周。第三组在口服吡虫啉4、8和12周之前，先以10 ml / kg体重的橄榄油（OLO）治疗2周。第四组在暴露于吡虫啉4、8和12周后，以10 ml / kg bw的剂量给予OLO，持续2周。收集骨髓用于微核和染色体畸变测定。结果表明，吡虫啉诱导在8一致突变作用^个和12^个暴露2周和OLO降低了吡虫啉对白化病大鼠的诱变作用，但并未完全使其恢复正常。