The ameliorating effect of different fractions of Anonna muricata ethanol leaves extract in oxidative pancreatic injury as well as their antihyperglycemic effect were investigated in vitro and ex vivo. Oxidative pancreatic injury was induced by incubating pancreatic tissue with ferrous sulphate (FeSO₄)_. The antioxidative potentials of the fractions together with its ability to inhibit carbohydrate digesting enzymes, intestinal glucose absorption, and its ability to modulate muscle glucose uptake were determined. All the fractions significantly scavenge free radicals in dose‐dependent manner and increase significantly increase the catalase and superoxide dimutase level thereby ameliorating lipid peroxidation. All the fractions also inihibited glucose digesting enzymes and absorption in dose‐dependent manner. Glucose uptake was enhanced by the fractions in isolated psoas muscle of rats. The ethyl acetate fraction showed more potent amelioration and anti‐hyperglycemic potentials among all the fractions. This could be further exploited as therapeutic strategy for the management of postprandial hyperglycemia as well as T2D.

中文翻译：

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来自番荔枝番荔枝的级分减轻了胰腺组织中的氧化应激，抑制了关键的碳水化合物消化酶和肠道葡萄糖的吸收，但增加了肌肉葡萄糖的吸收。

体外和离体研究了不同成分的番荔枝乙醇叶提取物对氧化性胰腺损伤的改善作用以及抗降血糖作用。硫酸亚铁（FeSO ₄）孵育胰腺组织引起氧化性胰腺损伤_。确定了级分的抗氧化潜力，以及其抑制碳水化合物消化酶的能力，肠道葡萄糖的吸收及其调节肌肉葡萄糖摄取的能力。所有组分均以剂量依赖性方式清除自由基，并增加其过氧化氢酶和超氧化物歧化酶水平，从而改善脂质过氧化作用。所有组分均以剂量依赖的方式抑制葡萄糖消化酶和吸收。通过分离大鼠腰大肌中的部分来增强葡萄糖摄取。乙酸乙酯馏分在所有馏分中均显示出更强的改善作用和降血糖潜力。这可以进一步用作治疗餐后高血糖以及T2D的治疗策略。