This study investigated the ameliorative effects of acid hydrolyzed celery extract (HCE) and celery extract (CE) in an atopic dermatitis (AD) mice model. The results of the study showed that HCE, more than CE improved AD‐like skin lesions caused by fluoro‐2,4‐dinitrobenzene and house dust mite antigen administration. Further analysis also showed the dominance of HCE than CE in preventing mast cell infiltration in the dermis; inhibiting the IL‐31 expression in mice skin and reducing the immunoglobulin‐E, IL‐4, IL‐5, TNF‐α, IFN‐γ, IL‐31, and TSLP in serum of mice. Using in vitro studies in a murine macrophage cell line, we showed that apigetrin, luteolin, and apigenin present in both extracts could be accountable for the observed effects as these three compounds and not apiin prevented the nitric oxide production in the murine macrophage. Based on this study, we suggest that hydrolyzing celery extracts can improve the therapeutic efficacy of celery extracts for management of AD.

中文翻译：

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水解芹菜提取物对小鼠的抗异位性皮炎作用。

这项研究调查了酸水解芹菜提取物（HCE）和芹菜提取物（CE）在特应性皮炎（AD）小鼠模型中的改善作用。研究结果表明，HCE优于CE改善了由氟-2,4-二硝基苯和屋尘螨抗原管理引起的AD样皮肤损害。进一步的分析还显示，HCE比CE在预防真皮中肥大细胞浸润方面具有优势。抑制小鼠皮肤中IL-31的表达并降低小鼠血清中的免疫球蛋白-E，IL-4，IL-5，TNF-α，IFN-γ，IL-31和TSLP。通过在鼠类巨噬细胞系中进行的体外研究，我们发现两种提取物中都存在的芹菜素，木犀草素和芹菜素可能是所观察到的效应的原因，因为这三种化合物而不是芹菜素都不能阻止鼠巨噬细胞中一氧化氮的产生。