Long noncoding RNA (lncRNA) AC026904.1 has been confirmed to be necessary for breast cancer metastasis. This work aims to investigate the effects of lncRNA AC026904.1 on lung cancer metastasis. We found that lncRNA AC026904.1 displayed a higher level in metastatic lung cancer tissues than adjacent tissues and nonmetastatic lung cancer tissues, and lung cancer cells treated with TGF-β. The expression of AC026904.1 was increased by the non-canonical TGF-β signaling. Additionally, AC026904.1 acts as an enhancer of the key metastatic factor Slug in the nucleus. This AC026904.1/Slug axis is necessary for TGF-β-mediated migration and epithelial-mesenchymal transition in lung cancer cells. This work firstly uncovers that AC026904.1 increases Slug expression at transcriptional level and subsequently plays critical effects in lung cancer metastasis, providing novel evidences that AC026904.1 holds great potential to be used as a marker for metastatic lung cancer.

中文翻译：

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长链非编码 RNA AC026904.1 通过在肺癌细胞中作为 Slug 的增强剂，对 TGF-β 诱导的迁移和上皮间质转化至关重要

长链非编码 RNA (lncRNA) AC026904.1 已被证实是乳腺癌转移所必需的。本工作旨在研究lncRNA AC026904.1对肺癌转移的影响。我们发现 lncRNA AC026904.1 在转移性肺癌组织中的水平高于邻近组织和非转移性肺癌组织，以及用 TGF-β 处理的肺癌细胞。AC026904.1 的表达因非经典 TGF-β 信号传导而增加。此外，AC026904.1 可作为细胞核中关键转移因子 Slug 的增强剂。这种 AC026904.1/Slug 轴是肺癌细胞中 TGF-β 介导的迁移和上皮间质转化所必需的。这项工作首先揭示了 AC026904.1 在转录水平上增加 Slug 表达，随后在肺癌转移中发挥关键作用，