The quality of life (QoL) of people with Alzheimer disease (PwAD) may be influenced by the type of relationship between carer and the PwAD. Dyads of 98 PwAD/carers (N = 49 spouse-carers; N = 49 nonspouses carers) were measured about QoL, cognition, dementia severity, awareness of disease, functionality, depression, anxiety, and burden of care. Univariate and multivariate regression analyses were conducted to identify the factors that influenced the spouse and nonspouse self-report PwAD QoL (PQOL) and to compare carers’ ratings of PwAD QoL (C-PQOL). The total score of QoL for spouse and nonspouse PwAD showed no significant difference (P = .29). The linear regression demonstrated that higher awareness of disease was significantly related to spouse PQOL (P = .001). Nonspouse PQOL was negatively related to lower depression (P = .007). The total score of QoL for spouse and nonspouse C-PQOL showed no significant difference (P = .14). The linear regression demonstrated that depression of spouse-PwAD (P < .001) and burden of care (P = .001) were negatively related to spouse-dyads’ C-PQOL. The nonspouse-dyads C-PQOL was negatively related to depression of nonspouse-PwAD (P < .001), awareness of disease (P = .001), and the mood of the carer (P = .01). Spouse and nonspouse PwAD evaluate PQOL better than carers (C-PQOL). No significant difference was found in the total PQOL and C-PQOL of spouse and nonspouse, but dyads evaluated differently about what is important to assess QoL.

阿尔茨海默病 (PwAD) 患者的生活质量 (QoL) 可能受照顾者与 PwAD 之间关系类型的影响。测量了 98 名 PwAD/照顾者（N = 49 名配偶照顾者；N = 49 名非配偶照顾者）的 QoL、认知、痴呆严重程度、疾病意识、功能、抑郁、焦虑和护理负担。进行单变量和多变量回归分析以确定影响配偶和非配偶自我报告 PwAD QoL (PQOL) 的因素，并比较照顾者对 PwAD QoL (C-PQOL) 的评级。配偶和非配偶 PwAD 的 QoL 总分没有显着差异（P = .29）。线性回归结果表明，较高的疾病意识与配偶 PQOL 显着相关（P= .001）。非配偶 PQOL 与较低的抑郁呈负相关 ( P = .007)。配偶和非配偶 C-PQOL 的 QoL 总分无显着差异（P = .14）。线性回归表明，配偶-PwAD 的抑郁 ( P < .001) 和护理负担 ( P = .001) 与配偶的 C-PQOL 呈负相关。非配偶二人 C-PQOL 与非配偶 PwAD 的抑郁 ( P < .001)、疾病意识 ( P = .001) 和照顾者的情绪 ( P= .01）。配偶和非配偶 PwAD 对 PQOL 的评估优于照顾者 (C-PQOL)。配偶和非配偶的总 PQOL 和 C-PQOL 没有发现显着差异，但二人对评估 QoL 的重要性的评估不同。