Anticancer agents often cause drug-induced tetraploidy (DIT) in cancer cells. DIT is not only a mechanism of inherited drug resistance, but proliferating DIT cells can produce progeny with increased ploidy or aneuploid genomes that drive aggressive disease. Here, we explore combinatorial therapeutic strategies for either preventing or eliminating DIT cells.

中文翻译：

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非霍奇金淋巴瘤中药物诱导的四倍体的两面性。

抗癌剂通常会在癌细胞中引起药物诱导的四倍体 (DIT)。DIT 不仅是遗传耐药性的一种机制，而且增殖的 DIT 细胞可以产生具有增加的倍性或非整倍体基因组的后代，从而驱动侵袭性疾病。在这里，我们探索预防或消除 DIT 细胞的组合治疗策略。