OBJECTIVES Life-course models have been infrequently applied to physical function. We sought to examine the effects of the cumulative burden of cardiovascular risk factors (CVRFs) from childhood on physical function in midlife. METHODS This longitudinal study consisted of 718 participants (aged 37 to 56 years at follow-up) who were examined for CVRFs at least four times during childhood and at least twice in adulthood, with 39 years of follow-up. We assessed physical function in 2013-2016 with the Short Physical Performance Battery (SPPB), 6-minute walking test (6MWT), and handgrip strength. The area under the growth curve (AUC) was used as a measure of cumulative exposure to CVRFs during childhood. RESULTS AUC of HDL-cholesterol levels in childhood were positively associated with SPPB score. AUC levels of body mass index (BMI) and triglycerides (TG) were inversely associated with 6MWT. Higher AUC levels of systolic/diastolic blood pressure (BP) predicted poorer hand grip strength. The number of childhood CVRFs in the top quartile, including AUC levels of BMI and TG, were inversely associated with 6MWT and remained significant after adjustment for the adulthood CVRFs. CONCLUSION Cumulative burden of CVRFs from childhood were associated with worse physical function in midlife independent of adulthood CVRFs.

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来自儿童期和中年时期身体机能的心血管危险因素：《博伽卢萨心脏研究》。

目的生命历程模型很少用于身体功能。我们试图研究儿童期心血管疾病危险因素（CVRFs）累积负担对中年人身体机能的影响。方法这项纵向研究由718名参与者（随访年龄37至56岁）组成，他们在儿童时期至少四次检查了CVRF，在成年期至少检查了两次，并进行了39年的随访。我们通过短物理性能电池（SPPB），6分钟步行测试（6MWT）和握力评估了2013-2016年的身体机能。生长曲线下的面积（AUC）被用作衡量儿童时期CVRF累积暴露的量度。结果儿童HDL胆固醇水平的AUC与SPPB评分呈正相关。体重指数（BMI）和甘油三酸酯（TG）的AUC水平与6MWT呈负相关。收缩压/舒张压（BP）的AUC值越高，预示的握力越差。最高四分位数的儿童CVRF数量（包括BMI和TG的AUC水平）与6MWT呈反比关系，并且在调整成年CVRF之后仍然保持显着水平。结论儿童期CVRF的累积负担与中年人独立于成年CVRFs的身体功能较差有关。