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Reciprocal Regulation of Mitochondrial Fission and Fusion.
Trends in Biochemical Sciences ( IF 13.8 ) Pub Date : 2020-04-11 , DOI: 10.1016/j.tibs.2020.03.009
Rasha Sabouny 1 , Timothy E Shutt 2
Affiliation  

The dynamic processes of mitochondrial fission and fusion are tightly regulated, determine mitochondrial shape, and influence mitochondrial functions. For example, fission and fusion mediate energy output, production of reactive oxygen species (ROS), and mitochondrial quality control. As our understanding of the molecular machinery and mechanisms regulating dynamic changes in the mitochondrial network continues to grow, we are beginning to unravel important signaling pathways that integrate physiological cues to modulate mitochondrial morphology and function. Here, we highlight reciprocal regulation of mitochondrial fusion and fission as an emerging trend in the regulation of mitochondrial function.



中文翻译:

线粒体裂变与融合的相互调节。

线粒体分裂和融合的动态过程受到严格调节,确定线粒体形状,并影响线粒体功能。例如,裂变和聚变介导能量输出,活性氧物质(ROS)的产生以及线粒体质量控制。随着我们对调节线粒体网络动态变化的分子机制和机制的理解不断增长,我们开始揭示重要的信号传导途径,这些途径整合了生理学信号来调节线粒体的形态和功能。在这里,我们强调线粒体融合和裂变的相互调节,作为线粒体功能调节的新兴趋势。

更新日期:2020-04-11
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