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Precise visual distinction of brain glioma from normal tissues via targeted photoacoustic and fluorescence navigation.
Nanomedicine: Nanotechnology, Biology and Medicine ( IF 5.4 ) Pub Date : 2020-04-12 , DOI: 10.1016/j.nano.2020.102204
Xiaohua Jia 1 , Kelong Fan 2 , Ruofei Zhang 3 , Dan Zhang 4 , Jianjun Zhang 5 , Yuan Gao 6 , Tao Zhang 7 , Wanjun Li 8 , Junlai Li 9 , Xiyun Yan 3 , Jie Tian 10
Affiliation  

The vexing difficulty in distinguishing glioma from normal tissues is a major obstacle to prognosis. In an attempt to solve this problem, we used a joint strategy that combined targeted-cancer stem cells nanoparticles with precise photoacoustic and fluorescence navigation. We showed that traditional magnetic resonance imaging (MRI) did not represent the true morphology of tumors. Targeted nanoparticles specifically accumulated in the tumor area. Glioma was precisely revealed at the cellular level. Tumors could be non-invasively detected through the intact skull by fluorescence molecular imaging (FMI) and photoacoustic tomography (PAT). Moreover, PAT can be used to excise deep gliomas. Histological correlation confirmed that FMI imaging accurately delineated scattered tumor cells. The combination of optical PAT and FMI navigation fulfilled the promise of precise visual imaging in glioma detection and resection. This detection method was deeper and more intuitive than the current intraoperative pathology.

中文翻译:

通过有针对性的光声和荧光导航,将大脑神经胶质瘤与正常组织进行精确的视觉区分。

区分神经胶质瘤与正常组织的烦恼是预后的主要障碍。为了解决这个问题,我们采用了联合策略,将靶向癌干细胞纳米颗粒与精确的光声和荧光导航相结合。我们表明,传统的磁共振成像(MRI)不能代表肿瘤的真正形态。靶向的纳米颗粒专门积聚在肿瘤区域。胶质瘤在细胞水平上被精确地揭示。可以通过荧光分子成像(FMI)和光声层析成像(PAT)通过完整的颅骨无创检测肿瘤。此外,PAT可用于切除深部神经胶质瘤。组织学相关性证实,FMI成像准确地描绘了散在的肿瘤细胞。光学PAT和FMI导航的结合实现了在胶质瘤检测和切除中进行精确视觉成像的希望。这种检测方法比当前的术中病理学更深入,更直观。
更新日期:2020-04-12
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