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The effect of hyperbaric oxygen on mitochondrial and glycolytic energy metabolism: the caloristasis concept.
Cell Stress and Chaperones ( IF 3.8 ) Pub Date : 2020-04-06 , DOI: 10.1007/s12192-020-01100-5
Didem Tezgin 1 , Charles Giardina 1 , George A Perdrizet 2 , Lawrence E Hightower 1
Affiliation  

We present new data on the effects of HBOT on human kidney (HK-2) cell metabolism using a SeaHorse XF Analyzer to evaluate separately the state of mitochondrial and glycolytic energy metabolism. The data are discussed in the context of the concept of cellular caloristasis networks. The information on the changes in cellular energy metabolism stimulated by HBOT presented here provides new insights into the cellular energy state and mitochondrial environment in which sHSPs function. These data will be useful in forming testable hypotheses about the functions of translocated sHSPs in human mitochondria responding to stressors.

中文翻译:

高压氧对线粒体和糖酵解能量代谢的影响:热量停滞概念。

我们使用 SeaHorse XF 分析仪提供了关于 HBOT 对人肾 (HK-2) 细胞代谢影响的新数据,以分别评估线粒体和糖酵解能量代谢的状态。这些数据是在细胞热量稳定网络概念的背景下讨论的。此处介绍的 HBOT 刺激的细胞能量代谢变化的信息提供了对 sHSP 起作用的细胞能量状态和线粒体环境的新见解。这些数据将有助于形成关于易位 sHSP 在响应压力源的人类线粒体中的功能的可检验假设。
更新日期:2020-04-06
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