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Antibodies to Heat Shock Proteins 90α and 90β in Psoriasis.
Archivum Immunologiae et Therapiae Experimentalis ( IF 3.2 ) Pub Date : 2020-04-01 , DOI: 10.1007/s00005-020-00573-7
Aleksandra Damasiewicz-Bodzek 1 , Magdalena Szumska 1 , Krystyna Tyrpień-Golder 1
Affiliation  

One of many hypotheses of psoriasis pathogenesis supposes an overexpression of heat shock proteins (Hsps) in different skin layers and systemic immunologic response to them. Hsp90 is one of the most abundant chaperone in eukaryotic cells. The number of studies concerning the role of Hsp90 and anti-Hsp90 antibodies in etiopathogenesis of various diseases is also constantly expanding. Still, there are not many reports concerning potential involvement of this Hsp family or anti-Hsp90 immunization in pathomechanism of psoriasis. The aim of the study was the estimation of anti-Hsp90α and anti-Hsp90β IgG antibodies in the sera of the psoriatic patients at different phases of disease activity in comparison to the sera of healthy individuals. The study material consisted of sera from psoriasis patients (n = 80) in active phase and in the remission phase and healthy individuals (n = 80). Concentrations of anti-Hsp90α and anti-Hsp90β IgG antibodies were determined using ELISA technique. In the patients with psoriasis (both in the active phase of the disease and in the remission phase) concentrations of anti-Hsp90α antibodies were significantly higher than in healthy individuals and they correlated positively with psoriasis area severity index values. The mean concentrations of anti-Hsp90β antibodies in the psoriatic patients and healthy controls were comparable. The obtained results indicate an existence of increased immunological response to Hsp90α in psoriasis. It may suggest the role of the extracellular form of this chaperone and/or anti-Hsp90α antibodies in etiopathogenesis of this dermatosis. The inhibition of Hsp90α may represent a novel therapeutic approach to treat psoriasis.

中文翻译:

银屑病中热休克蛋白90α和90β的抗体。

牛皮癣发病机制的许多假设之一是,热激蛋白(Hsps)在不同皮肤层中过表达,并对它们进行系统性免疫应答。Hsp90是真核细胞中最丰富的伴侣蛋白之一。关于Hsp90和抗Hsp90抗体在各种疾病的发病机制中的作用的研究数量也在不断扩大。但是,关于这种Hsp家族或抗Hsp90免疫可能参与牛皮癣发病机制的报道还很少。该研究的目的是与健康个体的血清相比,估计在疾病活动不同阶段的银屑病患者血清中的抗Hsp90α和抗Hsp90βIgG抗体。研究材料包括活跃期和缓解期的牛皮癣患者(n = 80)和健康个体(n = 80)的血清。使用ELISA技术确定抗Hsp90α和抗Hsp90βIgG抗体的浓度。在患有牛皮癣的患者中(无论是在疾病的活跃期还是在缓解期),抗Hsp90α抗体的浓度均显着高于健康个体,并且与牛皮癣面积严重性指数值呈正相关。银屑病患者和健康对照者中抗Hsp90β抗体的平均浓度相当。获得的结果表明在牛皮癣中对Hsp90α的免疫应答增加。这可能表明这种伴侣蛋白和/或抗Hsp90α抗体的细胞外形式在这种皮肤病的发病机理中的作用。Hsp90α的抑制可能代表治疗牛皮癣的一种新的治疗方法。
更新日期:2020-04-20
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