Although cell division is usually portrayed as an equitable process by which a progenitor cell originates two identical daughter cells, there are multiple examples of asymmetric divisions that generate two cells that differ in their content, morphology and/or proliferative potential. The capacity of the cells to generate asymmetry during their division is of paramount biological relevance, playing essential roles during embryonic development, cellular regeneration and tissue morphogenesis. Problems with the proper establishment of asymmetry and polarity during cell division can give rise to cancer and neurodevelopmental disorders, as well as to also accelerate cellular aging. Interestingly, the microtubule organizing centers that orchestrate the formation of the mitotic spindle have been described among the cellular structures that can be differentially allocated during asymmetric cell divisions. This mini-review focuses on recent research from our group and others uncovering a role for the non-random distribution of the spindle-associated microtubule organizing centers in the differential distribution of aging factors during asymmetric mitoses and therefore in the maintenance of the replicative lifespan of the cells.

中文翻译：

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非对称细胞分裂和复制性衰老：从纺锤极得到的新视角。

尽管通常将细胞分裂描绘成祖细胞起源于两个相同子细胞的公平过程，但存在多个不对称分裂的例子，这些不对称分裂产生了两个细胞，其内容，形态和/或增殖潜能不同。细胞在分裂过程中产生不对称的能力具有至关重要的生物学意义，在胚胎发育，细胞再生和组织形态发生中起着至关重要的作用。在细胞分裂过程中正确建立不对称和极性的问题会导致癌症和神经发育障碍，并加速细胞衰老。有趣的是 在不对称细胞分裂过程中可以差异分配的细胞结构中，已经描述了协调有丝分裂纺锤体形成的微管组织中心。这份小型综述的重点是我们小组和其他研究人员的最新研究，这些研究揭示了纺锤体相关微管组织中心的非随机分布在不对称有丝分裂期间衰老因子的差异分布中的作用，因此在维持复制性寿命方面发挥了作用。细胞。