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Advances of single-cell genomics and epigenomics in human disease: where are we now?
Mammalian Genome ( IF 2.5 ) Pub Date : 2020-04-08 , DOI: 10.1007/s00335-020-09834-4
Rizqah Kamies 1 , Celia P Martinez-Jimenez 1
Affiliation  

Cellular heterogeneity is revolutionizing the way to study, monitor and dissect complex diseases. This has been possible with the technological and computational advances associated to single-cell genomics and epigenomics. Deeper understanding of cell-to-cell variation and its impact on tissue function will open new avenues for early disease detection, accurate diagnosis and personalized treatments, all together leading to the next generation of health care. This review focuses on the recent discoveries that single-cell genomics and epigenomics have facilitated in the context of human health. It highlights the potential of single-cell omics to further advance the development of personalized treatments and precision medicine in cancer, diabetes and chronic age-related diseases. The promise of single-cell technologies to generate new insights about the differences in function between individual cells is just emerging, and it is paving the way for identifying biomarkers and novel therapeutic targets to tackle age, complex diseases and understand the effect of life style interventions and environmental factors.



中文翻译:

人类疾病中单细胞基因组学和表观基因组学的进展:我们现在在哪里?

细胞异质性正在彻底改变研究,监测和解剖复杂疾病的方式。随着与单细胞基因组学和表观基因组学相关的技术和计算进步,这已经成为可能。对细胞间变异及其对组织功能的影响的更深入了解将为早期疾病检测,准确诊断和个性化治疗开辟新途径,共同促成下一代医疗保健。这篇综述着重于单细胞基因组学和表观基因组学在人类健康背景下的最新发现。它强调了单细胞组学在进一步发展针对癌症,糖尿病和慢性老年性疾病的个性化治疗和精准医学方面的潜力。

更新日期:2020-04-22
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