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Neuroprotective Effects of Peptides in the Brain: Transcriptome Approach
Biochemistry (Moscow) ( IF 2.8 ) Pub Date : 2020-03-01 , DOI: 10.1134/s0006297920030037
I B Filippenkov 1 , L V Dergunova 1 , S A Limborska 1 , N F Myasoedov 1
Affiliation  

The importance of studying the action mechanisms of drugs based on natural regulatory peptides is commonly recognized. Particular attention is paid to the peptide drugs that contribute to the restoration of brain functions after acute cerebrovascular accidents (stroke), which for many years continues to be one of the main problems and threats to human health. However, molecular genetic changes in the brain in response to ischemia, as well as the mechanisms of protective effects of peptides, have not been sufficiently studied. This limits the use of neuroprotective peptides and makes it difficult to develop new, more efficient drugs with targeted action on brain functions. Transcriptome analysis is a promising approach for studying the mechanisms of the damaging effects of cerebral ischemia and neuroprotective action of peptide drugs. Beside investigating the role of mRNAs in protein synthesis, the development of new neuroprotection strategies requires studying the involvement of regulatory RNAs in ischemia. Of greatest interest are microRNAs (miRNAs) and circular RNAs (circRNAs), which are expressed predominantly in the brain. CircRNAs can interact with miRNAs and diminish their activity, thereby inhibiting miRNA-mediated repression of mRNAs. It has become apparent that analysis of the circRNA/miRNA/mRNA system is essential for deciphering the mechanisms of brain damage and repair. Here, we present the results of studies on the ischemia-induced changes in the activity of genes and peptide-mediated alterations in the transcriptome profiles in experimental ischemia and formulate the basic principles of peptide regulation in the ischemia-induced damage.

中文翻译:

肽在大脑中的神经保护作用:转录组方法

研究基于天然调节肽的药物作用机制的重要性是公认的。特别关注有助于在急性脑血管意外(中风)后恢复大脑功能的肽类药物,这多年来一直是人类健康的主要问题和威胁之一。然而,脑响应缺血的分子遗传变化以及肽的保护作用机制尚未得到充分研究。这限制了神经保护肽的使用,并使开发新的、更有效的对大脑功能具有靶向作用的药物变得困难。转录组分析是研究脑缺血损伤作用机制和肽类药物神经保护作用机制的一种很有前景的方法。除了研究 mRNA 在蛋白质合成中的作用外,新的神经保护策略的开发还需要研究调节性 RNA 在缺血中的参与。最令人感兴趣的是 microRNA (miRNA) 和环状 RNA (circRNA),它们主要在大脑中表达。circRNA 可以与 miRNA 相互作用并降低其活性,从而抑制 miRNA 介导的 mRNA 抑制。很明显,对 circRNA/miRNA/mRNA 系统的分析对于破译脑损伤和修复机制至关重要。在这里,我们介绍了缺血诱导的基因活性变化和实验性缺血转录组谱中肽介导的改变的研究结果,并阐述了缺血诱导损伤中肽调节的基本原理。
更新日期:2020-03-01
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