ABSRACT Context: Rhizoma Corydalis (RC) is the dried tubers of Corydalis yanhusuo (Y. H. Chou and Chun C. Hsu) W. T. Wang ex Z. Y. Su and C. Y. Wu (Papaveraceae). Traditionally, RC is used to alleviate pain such as headache, abdominal pain, and epigastric pain. Modern medicine shows that it has analgesic, anti-arrhythmia, and other effects. Objective: We provided an overview of the phytochemical and pharmacological properties of RC as a foundation for its clinical application and further research and development of new drugs. Methods: We collected data of various phytochemical and pharmacological effects of RC from 1982 to 2019. To correlate with existing scientific evidence, we used Google Scholar and the journal databases Scopus, PubMed, and CNKI. ‘Rhizoma Corydalis’, ‘phytochemistry’, and ‘pharmacological effects’ were used as key words. Results: Currently, more than 100 chemical components have been isolated and identified from RC, among which alkaloid is the pimary active component of RC. Based on prior research, RC has antinociceptive, sedative, anti-epileptic, antidepressive and anti-anxiety, acetylcholinesterase inhibitory effect, drug abstinence, anti-arrhythmic, antimyocardial infarction, dilated coronary artery, cerebral ischaemia reperfusion (I/R) injury protection, antihypertensive, antithrombotic, antigastrointestinal ulcer, liver protection, antimicrobial, anti-inflammation, antiviral, and anticancer effects. Conclusions: RC is reported to be effective in treating a variety of diseases. Current pharmacological studies on RC mainly focus on the nervous, circulatory, digestive, and endocrine systems, as well as drug withdrawal. Although experimental data support the beneficial effects of this drug, its physiological activity remains a concern. Nonetheless, this review provides a foundation for future research.

中文翻译：

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延胡索植物化学及现代药理研究进展

摘要 背景： 延胡索 (RC) 是延胡索 (YH Chou 和 Chun C. Hsu) WT Wang ex ZY Su 和 CY Wu (罂粟科) 的干燥块茎。传统上，RC用于缓解头痛、腹痛和上腹痛等疼痛。现代医学表明，它具有镇痛、抗心律失常等作用。目的：概述RC的植物化学和药理特性，为其临床应用和进一步研发新药奠定基础。方法：我们收集了 1982 年至 2019 年 RC 的各种植物化学和药理作用的数据。为了与现有的科学证据相关联，我们使用了 Google Scholar 和期刊数据库 Scopus、PubMed 和 CNKI。“延胡索”、“植物化学”和“药理作用”被用作关键词。结果：目前已从RC中分离鉴定出100多种化学成分，其中生物碱是RC的主要活性成分。基于先前的研究，RC具有镇痛、镇静、抗癫痫、抗抑郁和抗焦虑、抑制乙酰胆碱酯酶、戒毒、抗心律失常、抗心肌梗死、扩张冠状动脉、脑缺血再灌注（I/R）损伤保护作用，具有抗高血压、抗血栓、抗胃肠溃疡、保肝、抗菌、抗炎、抗病毒、抗癌等作用。结论：据报道，RC可有效治疗多种疾病。目前对 RC 的药理学研究主要集中在神经、循环、消化和内分泌系统，以及药物戒断。尽管实验数据支持这种药物的有益作用，但其生理活性仍然是一个问题。尽管如此，这篇综述为未来的研究奠定了基础。