ABSTRACT Frontostriatal dysfunction in Parkinson’s disease (PD) increases the risk for working memory (WM) impairment and depression, calling for counteractive measures. Computerised cognitive rehabilitation is a promising option, but targeted training protocols are lacking and lab-based training can be demanding due to the repeated visits. This study tested the feasibility and efficacy of home-based computerised training targeting mainly WM updating in PD. Fifty-two cognitively well-preserved PD patients were randomised to a WM training group and an active control group for five weeks of training (three 30-min sessions per week). WM training included three computerised adaptive WM tasks (two updating, one maintenance). The outcomes were examined pre- and post-training with trained and untrained WM tasks, tasks tapping other cognitive domains, and self-ratings of executive functioning and depression. Home-based training was feasible for the patients. The training group improved particularly on the updating training tasks, and showed posttest improvement on untrained WM tasks structurally similar to the trained ones. Moreover, their depression scores decreased compared to the controls. Our study indicates that patients with mild-to-moderate PD can self-administer home-based computerised WM training, and that they yield a similar transfer pattern to untrained WM tasks as has been observed in healthy older adults.

中文翻译：

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训练帕金森病的工作记忆更新：一项随机对照试验

摘要帕金森病 (PD) 的额纹状体功能障碍会增加工作记忆 (WM) 损伤和抑郁的风险，需要采取相应措施。计算机化的认知康复是一种很有前景的选择，但缺乏针对性的训练方案，而且由于重复访问，实验室培训可能要求很高。本研究测试了以 PD 中 WM 更新为主的家庭计算机化培训的可行性和有效性。52 名认知功能完好的 PD 患者被随机分配到 WM 训练组和主动对照组，进行 5 周的训练（每周 3 次 30 分钟的训练）。WM 培训包括三个计算机化的自适应 WM 任务（两个更新，一个维护）。在训练前和训练后的 WM 任务、挖掘其他认知领域的任务、和执行功能和抑郁的自我评价。以家庭为基础的培训对患者来说是可行的。训练组尤其在更新训练任务上有所改进，并在未经训练的 WM 任务上表现出与训练过的任务结构相似的后测改进。此外，与对照组相比，他们的抑郁评分下降。我们的研究表明，轻度至中度 PD 患者可以自行进行基于家庭的计算机化 WM 训练，并且他们产生与在健康老年人中观察到的未经训练的 WM 任务类似的转移模式。此外，与对照组相比，他们的抑郁评分下降。我们的研究表明，轻度至中度 PD 患者可以自行进行基于家庭的计算机化 WM 训练，并且他们产生与在健康老年人中观察到的未经训练的 WM 任务类似的转移模式。此外，与对照组相比，他们的抑郁评分下降。我们的研究表明，轻度至中度 PD 患者可以自行进行基于家庭的计算机化 WM 训练，并且他们产生与在健康老年人中观察到的未经训练的 WM 任务类似的转移模式。