Blending Polyetheretherketone (PEEK) with Polyvinyl alcohol (PVA) is promising to obtain a composite scaffold combining the excellent biomechanical properties of PEEK and the remarkable degradability of PVA. However, the weak interfacial bonding between nonpolar PEEK and polar PVA would result in poor mechanical properties. In this study, owing to its unique amphiphilic properties, graphene oxide (GO) was employed to enhance the interfacial bonding between PEEK and PVA in PEEK/PVA scaffolds that were fabricated by laser 3D printing. On the one hand, the large π-conjugated structure of GO formed strong π-π interactions with the benzene rings in PEEK. On the other hand, the oxygen-containing groups of GO formed strong hydrogen bonds with the hydroxyl groups of PVA. As a result, the interfacial free energy between PEEK and PVA decreased from 37.4 to 29.6 mJ/m² according to the harmonic-mean rule, and the PVA phase in PEEK matrix became much fine and uniform, indicating a reinforced interfacial bonding. Correspondingly, the strength and modulus of PEEK/PVA scaffolds increased by 97.16% and 147.06%, respectively, for a GO loading of 1%. Furthermore, the scaffolds exhibited good hydrophilicity and degradability, and promoted cell attachment and proliferation in vitro and osteogenic differentiation and bone regeneration in vivo.

将聚醚醚酮（PEEK）与聚乙烯醇（PVA）混合有望获得一种结合了PEEK优异的生物力学性能和PVA出色的可降解性的复合支架。但是，非极性PEEK和极性PVA之间的弱界面结合会导致较差的机械性能。在这项研究中，由于其独特的两亲特性，氧化石墨烯（GO）用于增强通过激光3D打印制造的PEEK / PVA支架中PEEK和PVA之间的界面结合。一方面，GO的大π共轭结构形成强π-π与PEEK中苯环的相互作用。另一方面，GO的含氧基团与PVA的羟基形成强氢键。结果，根据谐波均值规则，PEEK和PVA之间的界面自由能从37.4降低到29.6 mJ / m ²，并且PEEK基体中的PVA相变得非常细和均匀，表明增强了界面键合。相应地，当GO载荷为1％时，PEEK / PVA支架的强度和模量分别增加了97.16％和147.06％。此外，支架表现出良好的亲水性和降解性，并在体外促进细胞附着和增殖以及在体内促进成骨分化和骨再生。