Ketamine is increasingly used in clinical practice, and ketamine addiction is common in young individuals. There are limited reviews on the chronic effects of ketamine on the testes. Three groups of rats received saline or ketamine 50 mg/kg/day intraperitoneally for 6 weeks with or without a subsequent 4-week drug-free period. Serum follicle-stimulating hormone, luteinizing hormone, prolactin, and testosterone levels, as well as testicular malondialdehyde concentrations, were measured. Epididymal sperm parameters were assessed. Testicular tissues were examined by hematoxylin and eosin staining and immunohistochemical staining using caspase-3 and vimentin antibodies. Chronic ketamine injection significantly decreased the levels of the examined hormones and adversely affected sperm parameters. Testicular tissue showed a significant increase in caspase-3 expression. In addition, Sertoli cell shape and position were disrupted. These effects disappeared 4 weeks after drug withdrawal. Chronic ketamine treatment has revisable hazardous effects on the rat reproductive function. There is a need to increase the knowledge of physicians and the public regarding these harmful effects of ketamine.

氯胺酮在临床实践中越来越多地使用，氯胺酮成瘾在年轻人中很常见。关于氯胺酮对睾丸的慢性影响的评论很少。三组大鼠腹膜内接受生理盐水或氯胺酮50 mg / kg /天治疗6周，有无随后的4周无药期。测量血清促卵泡激素，促黄体激素，催乳激素和睾丸激素的水平，以及睾丸丙二醛的浓度。评估附睾精子参数。通过苏木精和曙红染色以及使用caspase-3和波形蛋白抗体的免疫组织化学染色检查睾丸组织。长期注射氯胺酮会显着降低所检查激素的水平，并对精子参数产生不利影响。睾丸组织显示caspase-3表达显着增加。此外，Sertoli细胞的形状和位置也被破坏。停药后4周，这些作用消失了。慢性氯胺酮治疗对大鼠生殖功能有可修正的危险影响。有必要增加医生和公众对氯胺酮的这些有害作用的了解。